List of Contributors. Preface. Part 1: Clinical Subtypes and Spectrum 1. Spectrum, Boundary, and Subtyping Issues: Implications for Treatment-Refractory Obsessive-Compulsive Disorder Eric Hollander and Cheryl M. Wong 2. Connection Between Obsessive-Compulsive Disorder and Body Dysmorphic Disorder Katharine A. Phillips 3. Tic-Related Versus Non-Tic-Related Obsessive-Compulsive Disorder James F. Leckman, Christopher J. McDougle, David L. Pauls, Bradley S. Peterson, Dorothy E. Grice, Robert A. King, Lawrence Scahill, Lawrence H. Price and Steven A. Rasmussen 4. Comorbid Schizophrenia: Implications for Treatment of Obsessive-Compulsive Disorder Matthew J. Byerly, Wayne K. Goodman and Carlos Cuadros Part 2: Pathophysiology and Etiology 5. Clinical and Family-Genetic Studies of Childhood Obsessive-Compulsive Disorder Gregory L. Hanna 6. Information-Processing Abnormalities in Obsessive-Compulsive Disorder Richard J. McNally 7. Issues in Cognitive Treatment of Obsessive-Compulsive Disorder Patricia van Oppen and Paul M.G. Emmelkamp 8. Investigating Cortico-Striatal Pathophysiology in Obsessive-Compulsive Disorders: Procedural Learning and Imaging Probes Scott L. Rauch and Cary R. Savage Part 3: Assessment 9. A Review of Assessment Measures for Obsessive-Compulsive Disorder Ulrike Feske and Dianne L. Chambless 10. Measuring Outcome in Drug Trials of Obsessive-Compulsive Disorder Suck Won Kim Part 4: Cognitive-Behavioral Treatments 11. Psychological Treatment of Refractory Obsessive-Compulsive Disorder and Related Problems Paul M. Salkovskis, Candida Richards and Elizabeth Forrester 12. Inpatient Treatment of Refractory Obsessive-Compulsive Disorder C.Alec Pollard 13. Cognitive and Behavioral Treatment of Obsessive-Compulsive Spectrum Disorders Fugen A. Neziroglu, Kevin P. Stevens, Brett Liquori and Jose A. Yaryura-Tobias 14. Predicting Treatment Outcome for Obsessive-Compulsive Disorder: Effects of Comorbidity Gail Steketee, Nathan J. Henninger and C.Alec Pollard Part 5: Drug and Other Somatic Treatments 15. Pharmacotherapy of Obsessive-Compulsive Disorder: Overview and Treatment-Refractory Strategies Teresa A. Pigott and Sheila Seay 16. Preferential Efficacy of Serotonergic Medication in Obsessive-Compulsive Disorder: From Practice to Theory Iulian Iancu, Pinhas N. Dannon, Michal Lustig, Yehuda Sasson and Joseph Zohar 17. Clomipramine in the Treatment of Obsessive-Compulsive Disorder Joseph DeVeaugh-Geiss and Richard Katz 18. Biological Approaches to Treatment-Resistant Obsessive-Compulsive Disorder Wayne K. Goodman, Herbert E. Ward, Anita S. Kablinger and Tanya K. Murphy 19. The Role of Neuroleptics in Treatment-Refractory Obsessive-Compulsive Disorder Christopher J. McDougle, C.Neill Epperson and Lawrence H. Price 20. Intravenous Clomipramine for Obsessive-Compulsive Disorder Brian A. Fallon and Michael R. Liebowitz 21. Benzodiazepines in the Treatment of Obsessive-Compulsive Disorder William A. Hewlett 22. Electroconvulsive Therapy in Treatment-Refractory Obsessive-Compulsive Disorder Matthew V. Rudorfer 23. Neurosurgical Treatment of Obsessive-Compulsive Disorder Michael A. Jenike Part 6: Combined Treatment 24. Combined Drug and Behavioral Treatments for Obsessive-Compulsive Disorder: Early Findings David A. Speigel 25. Cognitive Behavior Therapy and Pharmacotherapy for Obsessive-Compulsive Disorder: The NIMH-Sponsored Collaborative Study Michael J. Kozak, Michael R. Liebowitz and Edna B. Foa Part 7: Mechanisms of Action 26. The Mechanisms of Behavioral Treatment and the Problem of Therapeutic Failures Stanley Rachman and Rosamund Shafran 27. Understanding the Mechanism of Action of Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder: A Step Toward More Effective Treatments? Pierre Blier, Richard Bergeron, Graciela Piñeyro and Mostafa El Mansari 28. Specific Brain System Mediation of Obsessive-Compulsive Disorder Responsive to Either Medication or Behavior Therapy Louis R. Baxter, Jr., Robert F. Ackermann, Neal R. Swerdlow, Arthur Brody, Sanjaya Saxena, Jeffrey M. Schwartz, Jane M. Gregoritch, Paula Stoessel and Michael E. Phelps. About the Editors. Author Index. Subject Index.