The revised guide to the diagnosis, management, and treatment of blood disorders and cancer in childrenChildren with blood disorders and cancer are a unique population that require specialized diagnostic considerations and management. The Handbook of Pediatric Hematology and Oncology has been designed to provide clinicians of all levels with practical guidance through an up-to-date algorithmic approach to these conditions. Assembled by a team of experts from the world-class Children's Hospital & Research Center Oakland, this updated third edition:* Presents up-to-date management and treatment guidelines for the most common pediatric blood disorders and malignancies* Provides an updated algorithmic approach for the diagnosis and management of the most common conditions and suggested readings* Utilizes rapid-referral tables containing visual representations of symptoms, lab findings, differentials, and treatment guidance* Incorporates case studies covering different hematologic and oncologic conditions, such as hemolytic anemia, sickle cell disease, hemophilia, neuroblastoma, and sarcomas of the soft tissue and bone* Includes a useful formulary that lists chemotherapy agents, dosing, mechanism of action, pregnancy category, indications, and side effects* Covers transfusion medicine, stem cell transplantation, management of central venous catheters, acute pain management, oncologic emergencies, and chemotherapy basicsWith its direct guidance and portable design, the Handbook of Pediatric Hematology and Oncology: Children's Hospital & Research Center Oakland, Third Edition, will prove an invaluable resource to medical students, trainees and residents, pediatric hematology and oncology nurses, pediatricians, and early-career providers in pediatric hematology/oncology.

Preface ixAcknowledgments xi1 Approach to the Anemic Child 12 Hemolytic Anemia 153 Sickle Cell Disease 274 Thalassemia 515 Transfusion Medicine 636 Chelation Therapy 797 Approach to the Bleeding Child 858 Von Willebrand Disease 959 Hemophilia 10310 Thrombophilia 11111 The Neutropenic Child 11912 Thrombocytopenia 13313 Evaluation of the Child with a Suspected Malignancy 15714 Oncologic Emergencies 17315 Acute Leukemias 19116 Central Nervous System Tumors 21117 Hodgkin and Non-Hodgkin Lymphoma 22718 Wilms Tumor 23919 Neuroblastoma 24520 Sarcomas of the Soft Tissues and Bone 25321 Germ Cell Tumors 26522 Rare Tumors of Childhood 27523 Histiocytic Disorders 28724 Hematopoietic Stem Cell Transplantation 29525 Supportive Care of the Child with Cancer 31326 Central Venous Catheters 32327 Management of Fever in the Child with Cancer 33328 Acute Pain Management in the Inpatient Setting 34729 Palliative Care 36130 Chemotherapy Basics 37731 Guide to Procedures 39332 Treatment of Chemotherapy Extravasations 403Formulary 409Index 489