Highlighting international approaches; the book details strategies to minimize contamination, residue monitoring programs, and classes of drugs and chemicals that pose contaminant risk in livestock.* Focuses attention on drug and chemical residues in edible animal products* Covers novel computational, statistical, and mathematical strategies for dealing with chemical exposures in food animals* Details major drug classes used in food animal production and their residue risks* Highlights efforts at harmonizing and the differences among areas like US, EU, Canada, Australia, South America, China, and Asia, where the issue of chemical exposures has significant impact on livestock products* Ties veterinary clinical practice and the use of these drugs in food animals with regulatory standards and mitigation practices

Preface viiContributors ix1 Importance of Veterinary Drug Residues 1Ronald E. Baynes and Jim E. Riviere2 Pharmacokinetic Principles for Understanding Drug Depletion as a Basis for Determination ofWithdrawal Periods for Animal Drugs 9Sanja Modric3 Evaluation of Drug Residue Depletion in the Edible Products of Food-Producing Animals forEstablishing Withdrawal Periods and Milk Discard Times 35Dong Yan4 Establishing Maximum Residue Limits in Europe 49Kornelia Grein and Isaura Duarte5 Methods to Derive Withdrawal Periods in the European Union 65G. Johan Schefferlie and Stefan Scheid6 Population Pharmacokinetic Modeling to Predict Withdrawal Times 81Sharon E. Mason7 Physiologically Based Pharmacokinetic Modeling 95Jennifer Buur8 Residue Avoidance in Beef Cattle Production Systems 115Virginia Fajt and Dee Griffin9 Residue Avoidance in Dairy Cattle Production Systems 137Geof Smith10 Residue Avoidance in Aquaculture Production Systems 161Renate Reimschuessel11 Residue Avoidance in Small Ruminant Production Systems 193Kevin Anderson and Reha Azizoglu12 Residue Avoidance in Swine Production Systems 221Ronald E. Baynes and Glen Almond13 Confirmatory Methods for Veterinary Drugs and Chemical Contaminants in Livestock Commodities233Hui li14 The Food Animal Residue Avoidance Databank: An Example of Risk Management of VeterinaryDrug Residues 289Thomas W. Vickroy, Ronald E. Baynes, Lisa Tell and Jim E. Riviere15 Risk Management of Chemical Contaminants in Livestock 303Ronald E. Baynes and Jim E. RiviereIndex 313