Hemostasis and Thrombosis: Practical Guidelines in ClinicalManagementEdited byHussain I Saba MD, PhDProfessor of MedicineDirector of Hematology/Hemophilia/Hemostasis & ThrombosisCenterUSF College of MedicineProfessor EmeritusDepartment of Malignant HematologyMoffitt Cancer Center and Research InstituteTampa, FL, USAHarold R Roberts MDEmeritus Professor of Medicine and PathologyDivision of Hematology / OncologyUniversity of North CarolinaChapel Hill, NC, USAHemostasis and thrombosis is a hugely important, changing andcomplex area that impacts many other medical specialties, affectingat least 10 million people in the United States alone. It is vitalfor physicians to recognize abnormalities of hemostasis andthrombosis and to be able to address these problems in theirpatients.Hemostasis and Thrombosis: Practical Guidelines in ClinicalManagementcovers all aspects of the practicalmanagement of commonly encountered thrombotic and bleedingdisorders, with emphasis on clinical diagnosis, treatment, andday-to-day management. The most clinically relevant material fromthe literature has been carefully compiled, along with: Discussions of new and upcoming diagnostic and therapeuticmodalities Practical clinical advice for all those dealing withcoagulation, hemostasis and thrombosisWritten by world leading specialists contributing their expertisein succinct text and focusing on the latest clinical guidanceHemostasis and Thrombosis: Practical Guidelines in ClinicalManagement will benefit hematologists in training and inpractice working in the fields of coagulation, hemostasis andthrombosis.Titles of related interestPractical Hemostasis and Thrombosis, 2ndEditionhref="wiley.com/WileyCDA/Section/id-302475.html?query=Nigel+Key">KeyISBN 9781405184601Hemophilia and Hemostasis: A Case-Based Approach toManagement, 2nd EditionMa, ISBN 9780470659762Quality in Laboratory Hemostasis and Thrombosis, 2ndEditionhref="wiley.com/WileyCDA/Section/id-302475.html?query=Steve+Kitchen">KitchenISBN 9780470671191href="wiley.com/go/hematology">wiley.com/go/hematology

Contributors viiPreface xAcknowledgments xi1 Theories of Blood Coagulation: Basic Concepts and Recent Updates 1Dougald M. Monroe and Maureane Hoffman2 Vascular Endothelium, Influence on Hemostasis: Past and Present 14Hussain I. Saba and Sabiha R. Saba3 Coagulation Testing: Basic and Advanced Clinical Laboratory Tests 30Nils Egberg and Margareta Blombäck4 Factor VIII Deficiency or Hemophilia A: Clinical Bleeding and Management 45Pier Mannuccio Mannucci and Massimo Franchini5 Factor IX Deficiency or Hemophilia B: Clinical Manifestations and Management 57Raj S. Kasthuri, Harold R. Roberts, and Paul E. Monahan6 Factor XI Deficiency or Hemophilia C 71Charles E. Bane, Anne T. Neff, and David Gailani7 Factor VIII and IX Inhibitors in Hemophilia 82Meera Chitlur and Jeanne Lusher8 Treatment Options for Acquired Hemophilia 93Anjali Sharathkumar and David Green9 Factor XII Deficiency or Hageman Factor Deficiency 112Evi X. Stavrou and Alvin H. Schmaier10 Inherited Combined Factor Deficiency States 127Asma Latif and Louis Aledort11 Acute and Chronic Immune Thrombocytopenia: Biology, Diagnosis, and Management 137Samir Dalia and Benjamin Djulbegovic12 Disseminated Intravascular Coagulation: Diagnosis and Management 151Stephanie J. Davis and Craig M. Kessler13 Mechanisms of Fibrinolysis and Basic Principles of Management 169John W. Weisel and Rustem I. Litvinov14 Post-thrombotic Syndrome 186Jean-Philippe Galanaud and Susan R. Kahn15 Von Willebrand Disease: Clinical Aspects and Practical Management 197Francesco Rodeghiero, Alberto Tosetto, and Giancarlo Castaman16 Platelets in Hemostasis: Inherited and Acquired Qualitative Disorders 209Noman Ashraf and Hussain I. Saba17 Contributions of Platelet Polyphosphate to Hemostasis and Thrombosis 236James H. Morrissey18 Thrombotic Microangiopathy: Biology, Diagnosis, and Management 246Samir Dalia and Hussain I. Saba19 Hemostasis and Aging 259Lodovico Balducci20 Hemostatic Problems in Chronic and Acute Liver Disease 271Ton Lisman and Robert J. Porte21 Cancer and Thrombosis 284Erica A. Peterson and Agnes Y. Y. Lee22 An Update on Low-Molecular-Weight Heparins 296Jawed Fareed, Debra Hoppensteadt, and Walter P. JeskeIndex 315