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Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models
ISBN-13:
9781118784617
Veröffentl:
2014
Einband:
E-Book
Seiten:
320
Autor:
Joel S. Owen
eBook Typ:
EPUB
eBook Format:
Reflowable
Kopierschutz:
2 - DRM Adobe
Sprache:
Englisch
Beschreibung:
This book provides a user-friendly, hands-on introduction to theNonlinear Mixed Effects Modeling (NONMEM) system, the most powerfultool for pharmacokinetic / pharmacodynamic analysis.* Introduces requisite background to using NonlinearMixed Effects Modeling (NONMEM), covering data requirements, modelbuilding and evaluation, and quality control aspects* Provides examples of nonlinear modeling concepts andestimation basics with discussion on the model buildingprocess and applications of empirical Bayesian estimates in thedrug development environment* Includes detailed chapters on data set structure,developing control streams for modeling and simulation, modelapplications, interpretation of NONMEM output and results, andquality control* Has datasets, programming code, and practice exerciseswith solutions, available on a supplementary website
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