Signalling Pathways in Liver Diseases 3E again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signalling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.With increased focus on the comprehension of cellular mechanisms involved in steatohatitis, cirrhosis and liver tumours, which has led in changes to the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:* Autophagy* Notch Pathway* PI3K/PTEN Signaling in Liver Diseases* Sirtuins* Hepcidin and Iron* Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis* Oxidative Stress and Signaling in the LiverProfessors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom will provide write a clear yet comprehensive review of their chosen topic. Chapters will contain clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.Signalling Pathways in Liver Diseases 3E is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

List of Contributors, vii1 Hepatocytes 1Jean-François Dufour and Joachim C. Mertens2 Signaling pathways in biliary epithelial cells 15M. Fatima Leite, Mateus T. Guerra, Viviane A. Andrade and Michael H. Nathanson3 Stellate cells 34Alessandra Caligiuri and Fabio Marra4 Kupffer cells 61Amirali Kiyani and Ekihiro Seki5 Hepatic sinusoidal endothelial cells 73Moira B. Hilscher Robert C. Huebert and Vijay H. Shah6 Extracellular matrix 85Scott L. Friedman7 Platelets: a new cell type in liver physiology 97Mickaël Lesurtel and Pierre?]Alain Clavien8 Immune cell communication in liver disease and liver regeneration 110R. Harminder Boghal, B.F. Stephenson and Simon C. Afford9 Extracellular vesicle RNA in liver disease 130Tushar Patel and Hiroaki Haga10 Endoplasmic reticulum stress in nonalcoholic fatty liver disease 139Fabienne Foufelle and Pascal Ferré11 Autophagy 151Hao Zhang, Bilon Khambu and Xiao?]Ming Yin12 CXC chemokine receptor signaling in liver repair and regeneration 166Gregory C. Wilson, Christopher M. Freeman, Hiroyuki Nojima and Alex B. Lentsch13 Metabolic regulation of liver regeneration 174Jiansheng Huang and David A. Rudnick14 TNF signaling 186Amrit Mann, Mark J. Czaja and Jörn M. Schattenberg15 Fas/FasL 203Maria Eugenia Guicciardi and Gregory J. Gores16 Interferon signaling 214Markus H. Heim17 Endocannabinoid signaling in liver pathologies 226Bostjan Humar and Nasser Semmo18 The WNT/ß?]catenin pathway 240Satdarshan P. Singh Monga19 Hedgehog signaling in the liver 262Mariana V. Machado and Anna Mae Diehl20 Notch pathway 275Sonja Rothweiler and David Semela21 PI3K/PTEN signaling in liver diseases 287Alfredo Fort, Nicolas Calo, Dorothea Portius, Lucie Bourgoin, Marion Peyrou and Michelangelo Foti22 mTOR signaling in liver disease 314Marion Cornu, Grégoire de Caudron de Coquereaumont and Michael N. Hall23 LKB1/AMPK pathway in the control of hepatic energy metabolism 326Benoit Viollet and Marc Fortes24 NF-kappaB 339Ekihiro Seki and David A. Brenner25 c-Jun NH2?]terminal kinases in liver diseases 348Johannes Kluwe and Robert F. Schwabe26 p53 364Aundrietta D. Duncan, Wen?]Wei Tsai and Michelle Craig Barton27 Sirtuins 374Frank K. Huynh, Eoin McDonnell, Kristin A. Anderson and Matthew D. Hirschey28 Bile acids and their receptors 385Thierry Claudel and Michael Trauner29 Hepcidin and iron 400Chiara Vecchi and Antonello Pietrangelo30 Gut microbiome and liver diseases 411Herbert Tilg and Alexander R. Moschen31 Epigenetic regulation of hepatic stellate cells and liver fibrosis 421Jelena Mann and Derek A. Mann32 Signaling in hepatocellular carcinoma 435Adam Pennycuick and Augusto Villanueva33 Interplay between hepatitis B virus and innate immune signaling pathways 448Barbara Testoni, David Durantel and Fabien Zoulim34 Signaling of hepatitis C virus 459Joachim Lupberger, Nicolaas Van Renne and Thomas F. Baumert35 Oxidative stress and signaling in the liver 469Mitchell R. McGill, Yuchao Xie and Hartmut JaeschkeIndex 000