The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives.The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy.Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.

Contributors ixPreface xiiiPart I: Vitamin A metabolic and enzymatic pathways 11 Vitamin a Metabolism, Storage and Tissue Delivery Mechanisms 3William S. Blaner and Yang Li2 Assimilation and Conversion of Dietary Vitamin a into Bioactive Retinoids 35Earl H. Harrison and Carlo dela Senã's3 Intracellular Storage and Metabolic Activation of Retinoids: Lipid Droplets 57Joseph L. Napoli and Charles R. Krois4 Evolution of the Retinoic Acid Signaling Pathway 75Vincent Laudet, Elisabeth Zieger, and Michael SchubertPart II: Biochemistry and cellular biology of retinoic acid signaling 915 Control of Gene Expression by Nuclear Retinoic Acid Receptors: Post-Translational And Epigenetic Regulatory Mechanisms 93Marilyn Carrier and Cécile Rochette-Egly6 Retinoic Acid Receptor Coregulators in Epigenetic Regulation of Target Genes 117Li-Na Wei7 Retinoid Receptors: Protein Structure, Dna Recognition and Structure-Function Relationships 131William Bourguet and Dino Moras8 How the RAR-RXR Heterodimer Recognizes the Genome 151Sylvia Urban, Tao Ye, and Irwin Davidson9 Retinoid Receptor-Selective Modulators: Chemistry, 3D Structures and Systems Biology 165Marco-Antonio Mendoza-Parra, William Bourguet, Angel R. de Lera, and Hinrich Gronemeyer10 Use of Retinoid Receptor Ligands to Identify Other Nuclear Receptor Ligands: Retinoid-Related Molecules are Ligands for the Small Heterodimer Partner (SHP) "Orphan" Receptor 193Marcia I. Dawson and Zebin Xia11 The Dual Transcriptional Activity of Retinoic Acid 273Noa Noy12 Retinoids, epigenetic changes during stem cell differentiation, and cell lineage choice 291Lorraine J. GudasPart III: RETINOIC ACID SIGNALING IN DEVELOPMENT 30713 Retinoic Acid Signaling and Central Nervous System Development 309Malcolm Maden14 The Role of Retinoic Acid in Limb Development 339Gregg Duester15 Retinoic Acid Signaling and Heart Development 353Stéphane Zaffran and Karen Niederreither16 Retinoic Acid in the Developing Lung and Other Foregut Derivatives 371Wellington V. Cardoso and Felicia Chen17 Retinoic Acid and the Control of Meiotic Initiation 383Josephine Bowles and Peter KoopmanPart IV: RETINOIDS AND PHYSIOLOGICAL FUNCTIONS 40118 Retinoids and the Visual Cycle: New Actors for an "OLD" Function 403Darwin Babino and Johannes von Lintig19 Retinoid Signaling in the Central Nervous System 421Peter McCaffery and Wojciech Krezel20 Retinoid Turnover and Catabolism: Influences of Diet and Inflammation 449A. Catharine Ross and Reza Zolfaghari21 Retinoids and the Immune System 465J. Rodrigo Mora and Makoto Iwata22 Retinoic Acid Receptor Signaling in Post-Natal Male Germ Cell Differentiation 485Manuel Mark and Norbert B. GhyselinckPart V: RETINOIDS, DISEASE AND THERAPY 50523 Epidemiology and Prevention of Vitamin a Deficiency Disorders 507Keith P. West, Jr.24 Retinoid Pathway Gene Mutations and the Pathophysiology Of Related Visual Diseases 529Yaroslav Tsybovsky and Krzysztof Palczewski25 Retinoic Acid in Acute Myeloid Leukemias 543Hugues de Thé and Pierre Fenaux26 Advances in the Use of Retinoids in Cancer Therapy and Prevention 557Michael J. Spinella, Sarah J. Freemantle, and Ethan DmitrovskyIndex 575