Beschreibung:
Methods and Applications of Statistics in Clinical Trials,Volume 2: Planning, Analysis, and Inferential Methods includesupdates of established literature from the Wiley Encyclopedia ofClinical Trials as well as original material based on the latestdevelopments in clinical trials. Prepared by a leading expert, thesecond volume includes numerous contributions from currentprominent experts in the field of medical research. In addition,the volume features:* Multiple new articles exploring emerging topics, such asevaluation methods with threshold, empirical likelihood methods,nonparametric ROC analysis, over- and under-dispersed models, andmulti-armed bandit problems* Up-to-date research on the Cox proportional hazardmodel, frailty models, trial reports, intrarater reliability,conditional power, and the kappa index* Key qualitative issues including cost-effectivenessanalysis, publication bias, and regulatory issues, which arecrucial to the planning and data management of clinical trials