Quality in Laboratory Hemostasis and ThrombosisSecond EditionEdited bySteve Kitchen, Clinical Scientist, Sheffield Haemophiliaand Thrombosis Centre, Royal Hallamshire Hospital and ScientificDirector, UK National External Quality Assessment Scheme (FQAS) forBlood Coagulation, Scientific Director, WHO and WFH InternationalExternal Quality Assessment Programs for Blood Coagulation,Sheffield, UKJohn D Olson, Professor and Vice Chair for ClinicalAffairs, Department of Pathology, University of Texas HealthSciences Centre, San Antonio, Texas, USAF. Eric Preston, Emeritus Professsor of Haematology,University of Sheffield and Director, WHO and WFH InternationalExternal Quality Assessment Programs for Blood Coagulations,Sheffield, UKThe hemostasis laboratory has a vital role in the diagnosis andmanagement of patients with familial and acquired hemorrhagic andthrombotic disorders. Rapid changes in the number and complexity oftests in this discipline have presented challenges forlaboratories, as they develop quality programs for the oversight ofthis testing.Quality in Laboratory Hemostasis and Thrombosis has beencompletely revised and updated to reflect the changing process ofmanaging quality. The second edition provides information on allaspects of testing, from pre-analytic to analytic and resultreporting, in addition to external quality assurance. Chaptersthroughout the book include the development of global guidelinesfor methods, as well as the preparation of international standardplasmas and reagents.Designed to capture the elements of quality at all levels of thepractice of laboratory hemostasis and thrombosis, this book willguide the reader through the development of a quality program tosupport all activities in the hemostasis laboratory, both simpleand complex.Titles of related interestLee: Textbook of Hemophilia, 2e (2010)ISBN 9781405169141Federici: Von Willebrand Disease: Basic and Clinical Aspects, 1e(2011)ISBN 9781405195126Ma: Hemophilia and Hemostasis: A Case Based Approach toManagement, 2e (2012)ISBN 9780470659762

Contributors, viiForeword, xPreface, xiiSteve Kitchen, John D. Olson, & F. Eric PrestonPart 1: General Quality Program1 General quality planning in the hemostasis laboratory, 3John D. Olson2 Hemostasis test validation, performance, and referenceintervals: international recommendations and guidelines, 12Richard A. Marlar3 Causes of errors in medical laboratories, 22Giuseppe Lippi & Emmanuel J. Favaloro4 International standards in hemostasis, 32Trevor W. Barrowcliffe & Anthony R. Hubbard5 Sample integrity and preanalytical variables, 45Dorothy (Adcock) Funk6 Internal quality control in the hemostasis laboratory,57Steve Kitchen, F. Eric Preston, & John D. Olson7 External quality assessment in hemostasis: its importance andsignificance, 65F. Eric Preston, Steve Kitchen, & Alok Srivastava8 The unique challenges of hemostatic testing in children,77M. Patricia Massicotte, Mary E. Bauman, Vanessa Chan, &Anthony K.C. ChanPart 2: Quality in Coagulation Testing9 Initial evaluation of hemostasis: reagent and methodselection, 95Wayne L. Chandler10 Assay of factor VIII and other clotting factors, 105Steve Kitchen & F. Eric Preston11 Application of molecular genetics to the investigation ofinherited bleeding disorders, 115Stefan Lethagen, Morten Dunø, & Lars Bo Nielsen12 Detecting and quantifying acquired functional inhibitors inhemostasis, 124Bert Verbruggen, Myriam Dardikh, & Britta Laros-vanGorkom13 Standardization of d-dimer testing, 136Guido Reber & Philippe de Moerloose14 Point-of-care testing in hemostasis, 147Chris Gardiner, Dianne Kitchen, Samuel Machin, & IanMackiePart 3: Quality in Testing for Platelet Function and vonWillebrand Disease15 Diagnostic assessment of platelet function, 159Paquita Nurden, Alan Nurden, & MartineJandrot-Perrus16 Laboratory evaluation of heparin-induced thrombocytopenia,174Theodore (Ted) E. Warkentin & Jane C. Moore17 Laboratory evaluation of von Willebrand disease: phenotypicanalysis, 192Emmanuel J. Favaloro18 Laboratory analysis of von Willebrand disease: molecularanalysis, 204Anne C. Goodeve & Ian R. PeakePart 4: Quality in Thrombophilia Testing and MonitoringAnticoagulation19 Quality issues in heritable thrombophilia testing, 219Isobel D. Walker & Ian Jennings20 Evaluation of antiphospholipid antibodies, 233Michael Greaves21 Monitoring heparin therapy, 244Marilyn Johnston22 Monitoring oral anticoagulant therapy with vitamin Kantagonists, 253Armando Tripodi23 Monitoring new anticoagulants, 264Elaine Gray & Trevor W. BarrowcliffeIndex, 273