The pace of therapeutic advances in the treatment ofcardiovascular diseases is rapid, and new clinically-relevantinformation appears with such frequency that it can be extremelychallenging for clinicians to keep up.Still, knowledge and interpretation of major clinical trials iscrucial for the range of clinicians who manage cardiovascularpatients, especially since important trial evidence often needs tobe implemented soon after it is published.Confidently apply gold standard treatment for 10 of the mostcritical areas of cardiologyWritten by an international team of experts,Cardiovascular Clinical Trials: Putting the Evidence intoPractice:* Provides a succinct overview of recent major clinical trials -the gold standard for all medical treatment - across all the majorcardiovascular subspecialties, to ensure you're up-to-date onthe most critical findings* Guides cardiology trainees and clinicians on how cardiovascularclinical trials are designed and conducted, including statisticalmethodology, so you can conduct and/or appraise future trialsyourself* Addresses methodology as well as clinical effectiveness* Offers evidence-based assessments on the most effectivetreatments and authoritative clinical information on management ofthe conditions so you can confidently apply what you learnPhysicians, surgeons, specialist nurses - any clinicianseeking an accessible resource for designing and conductingcardiovascular trials and then translating their results intopractice will appreciate this book's clear guidance andsuccinct and practical approach.

List of Contributors viiiPreface xList of Abbreviations xi1 Introduction to randomized clinical trials in cardiovascular disease 1Tobias Geisler, Marcus D. Flather, Deepak L. Bhatt, and Ralph B. D'Agostino, Sr2 Publishing results of clinical trials and reviewing papers for publication 44Tobias Geisler and Marcus D. Flather3 Management of chronic coronary artery disease 60Sabu Thomas and William E. Boden4 Acute coronary syndromes (ST elevation and non-ST elevation) 86Tobias Geisler, Deepak L. Bhatt, and Marcus D. Flather5 Heart failure 117Christopher M. O'Connor and Wendy Gattis Stough6 Atrial fibrillation 143Chee W. Khoo and Gregory Y.H. Lip7 Electrophysiology and pacing 174Irina Suman-Horduna and Sabine Ernst8 Percutaneous coronary intervention 205Dharam J. Kumbhani and Deepak L. Bhatt9 Randomized controlled trials in cardiac surgery: is there any alternative? 243Thanos Athanasiou, Amir Sepehripour, and John Pepper10 Adult congenital heart disease 274Cary Ward, J. Kevin Harrison, and Thomas M. Bashore11 Cardiac imaging 296Aiden Abidov and Daniel S. Berman12 Prevention of cardiovascular disease 345Alice J. Owen and Christopher M. ReidIndex 378