Covers the vastly expanding subject of oxidative processesmediated by copper ions within biological systemsCopper-mediated biological oxidations offer a broad range offundamentally important and potentially practical chemicalprocesses that cross many chemical and pharmaceutical disciplines.This newest volume in the Wiley Series on ReactiveIntermediates in Chemistry and Biology is divided into threelogical areas within the topic of copper/oxygen chemistry--biological systems, theory, and bioinorganic models andapplications--to explore the biosphere for its highly evolvedand thus efficient oxidative transformations in the discovery ofnew types of interactions between molecular oxygen and copper ion.Featuring a diverse collection of subject matter unified in onecomplete and comprehensive resource, Copper-Oxygen Chemistry probesthe fundamental aspects of copper coordination chemistry, syntheticorganic chemistry, and biological chemistry to reveal both thebiological and chemical aspects driving the current excitingresearch efforts behind copper-oxygen chemistry. In addition,Copper-Oxygen Chemistry:* Addresses the significantly increasing literature on oxygen-atominsertion and carbon-carbon bond-forming reactions as well asenantioselective oxidation chemistries* Progresses from biological systems to spectroscopy and theory,and onward to bioinorganic models and applications* Covers a wide array of reaction types such as insertion anddehydrogenation reactions that utilize the cheap, abundant, andenergy-containing O2 moleculeWith thorough coverage by prominent authors and researchersshaping innovations in this growing field, this valuable referenceis essential reading for bioinorganic chemists, as well as organic,synthetic, and pharmaceutical chemists in academia andindustry.

Preface to Series viiIntroduction ixContributors xi1 Insights into the Proposed Copper-Oxygen Intermediatesthat Regulate the Mechanism of Reactions Catalyzed by Dopamineb-Monooxygenase, Peptidylglycine a-Hydroxylating Monooxygenase, andTyramine b-Monooxygenase 1Robert L. Osborne and Judith P. Klinman2 Copper Dioxygenases 23Jozsef Kaizer, Jozsef Sandor Pap, and Gabor Speier3 Amine Oxidase and Galactose Oxidase 53Dalia Rokhsana, Eric M. Shepard, Doreen E. Brown, and David M.Dooley4 Energy Conversion and Conservation by Cytochrome Oxidases107Angela Paulus and Simon de Vries5 Multicopper Proteins 131Takeshi Sakurai and Kunishige Kataoka6 Structure and Reactivity of Copper-Oxygen SpeciesRevealed by Competitive Oxygen-18 Isotope Effects 169Justine P. Roth7 Theoretical Aspects of Dioxygen Activation in Dicopper Enzymes197Kazunari Yoshizawa8 Chemical Reactivity of Copper Active-Oxygen Complexes225Shinobu Itoh9 Cytochrome c Oxidase and Models 283Zakaria Halime and Kenneth D. Karlin10 Supramolecular Copper Dioxygen Chemistry 321Jean-Noel Rebilly and Olivia Reinaud11 Organic Synthetic Methods Using Copper Oxygen Chemistry361Marisa C. KozlowskiIndex 445