Complete, up-to-date coverage of the broad area of nucleic acidchemistry and biologyAssembling contributions from a collection of authors withexpertise in all areas of nucleic acids, medicinal chemistry, andtherapeutic applications, Medicinal Chemistry of NucleicAcids presents a thorough overview of nucleic acidchemistry--a rapidly evolving and highly challengingdiscipline directly responsible for the development of antiviraland antitumor drugs. This reliable resource delves into a multitudeof subject areas involving the study of nucleic acids--such asthe new advances in genome sequencing, and the processes forcreating RNA interference (RNAi) based drugs--to assistpharmaceutical researchers in removing roadblocks that hinder theirability to predict drug efficacy. Offering the latest cutting-edgescience in this growing field, Medicinal Chemistry of Nucleic Acidsincludes:* In-depth coverage of the development and application of modifiednucleosides and nucleotides in medicinal chemistry* A close look at a large range of current topics on nucleic acidchemistry and biology* Essential information on the use of nucleic acid drugs to treatdiseases like cancer* A thorough exploration of siRNA for RNAi and the regulation ofmicroRNA, non-coding RNA (ncRNA), a newly developing and excitingresearch areaThorough in its approach and promising in its message,Medicinal Chemistry of Nucleic Acids probes the new domainsof pharmaceutical research--and exposes readers to a wealth ofnew drug discovery opportunities emerging in the dynamic field ofnucleic acid chemistry.

FOREWORD viiCONTRIBUTORS xiINTRODUCTION xv1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS ANDBIOLOGICAL ACTIVITY 1Jianing Wang, Ravindra K. Rawal, and Chung K. Chu2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se,AND Te AND COMPLEXED WITH SMALL MOLECULES 101Wen Zhang, Jia Sheng, and Zhen Huang3 UNRAVELING OF THE NAD CYCLIZING AND CALCIUM SIGNALINGFUNCTIONS OF HUMAN CD38 142Hon Cheung Lee4 DNA AND RNA BINDING SMALL MOLECULES 164Shibo Li and Zhen Xi5 G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY206Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, andLian-Quan Gu6 MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN258Lidan Sun, Hongwei Jin, Liangren Zhang, and Lihe Zhang7 STRUCTURE OF 10-23 DNAzyme IN COMPLEX WITH THE TARGETRNA IN SILICO--A PROGRESS REPORT ON THE MECHANISM OFRNA CLEAVAGE BY DNA ENZYME 272Oleksandr Plashkevych and Jyoti Chattopadhyaya8 LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE292Il Joon Lee and Byeang Hyean Kim9 LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICALAPPLICATIONS 335Rakesh N. Veedu and Jesper Wengel10 THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS 349Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao,Caihong Liu, and Ying Wang11 INDUCIBLE RNAi AND DRUG TARGET VALIDATION 390Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng,Qiu-Chen He, Li-He Zhang, and De-Min Zhou12 siRNA: THE SPECIFICITY AND OFF-TARGET EFFECTS 405Quan Du, Huang Huang, and Zicai LiangINDEX 423