Our understanding of cancer has expanded in multiple directions including pathophysiological, biochemical, toxicological, and pharmacological aspects. Collectively, these areas will strengthen the ability to harness the greater benefit of oncology research to improve patient survival and quality of life and this is illustrated in this volume.

Overview and Current Status of Cancer; Introduction; Incidence, Mortality, and Prevention; Diagnosis and Pathobiology; Introduction; Diagnosis; Evolutionary Paradigms and Origin of Cancer; Heterogeneity and Dynamics of Cancer; Hallmarks of Cancer; Molecular Biology of Carcinogenesis; Genetic Underpinnings; Epigenetic Underpinnings; Characteristics, Events, and Stages in Tumorigenesis; Introduction; Metastases and the Microenvironment; Cell-of-Origin, Disseminated and Circulating Tumor Cells, and Cancer Stem Cells;Tumor-derived Exosomes and Particles; Oncogenic Viruses;Metabolic Syndrome and Cancer Metabolism; Convoluted Neovascularization; Treatments and Challenges; Introduction; Chemotherapy, Radiotherapy, and Targeted Therapy; Immunotherapy; Drug Resistance and Cellular Reprogramming; Efficient Biomarkers; The Role of Nutraceuticals and Natural Products; Physiologically Relevant Nutrikinetics and Nutridynamics; Additional Remarks, Perspectives, and Conclusions; References