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Target Organ Toxicity, Volume I
ISBN-13:
9781000722369
Veröffentl:
2020
Seiten:
242
Autor:
Gerald M. Cohen
eBook Typ:
EPUB
eBook Format:
EPUB
Kopierschutz:
0 - No protection
Sprache:
Englisch
Beschreibung:
This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.
Chapter 1 Basic Principles of Target Organ Toxicity, Chapter 2 Role of Pharmacokinetics in Rationalizing Tissue Distribution, Chapter 3 The Role of Metabolic Activation in Target Organ Toxicity, Chapter 4 Role of Excretion, Chapter 5 Species Variation in Target Organ Toxicity, Chapter 6 The Importance of Tissue-Specific Biochemistry in the Determination of Target Organ Toxicity, Chapter 7 Role of Key Defense Systems in Target Organ Toxicity, Chapter 8 The Liver as a Target Organ for Toxicity, Chapter 9 The Nervous System as a Target Organ for Toxicity, Index
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