Beschreibung:
Developing a model-based approach that enables any cross-over trial, of any degree of imbalance, to be analyzed both for direct effects and for residual effects using consistent procedures that employ commercially available statistical software, this timely reference/ text offers a thorough guide to the analysis of cross-over designs.
Introduction to the analysis of cross-over designs - basic principles and some useful tools; Latin square designs; the 2-treatment, 2-period, 2-sequence design; modifications of the 2-treatment, 2-period, 2-sequence design; cross-over designs with variance balance; cross-over designs lacking variance balance; the analysis of categorical data from cross-over designs; ordinary least squares estimation versus other criteria of estimation - justification for using the methodology presented in this book; other topics in cross-over designs.