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The Third Histamine Receptor
Selective Ligands as Potential Therapeutic Agents in CNS Disorders
Sofort lieferbar | Lieferzeit: Sofort lieferbar I
ISBN-13:
9781000687361
Veröffentl:
2008
Seiten:
400
Autor:
Divya Vohora
eBook Typ:
EPUB
eBook Format:
EPUB
Kopierschutz:
0 - No protection
Sprache:
Englisch
Beschreibung:
Since their discovery, the potential of histamine H3 receptor ligands in various CNS disorders have received much attention. This resource presents recent advances with an emphasis on pharmacology. It covers identification and localization of receptors and the development of novel ligands incorporating pre-clinical and clinical studies indicating earliest possible stages of development. The book provides an overview of histamine as a neurotransmitter and discusses receptor pharmacology, signal transduction, selective ligands, and therapeutic potential. Several chapters address disorders involving H3, including Alzheimer's, ADHD, sleep disorders, epilepsy, obesity, and psychiatric and neurodegenerative disorders.
INTRODUCTION. H3 Receptor Target: Past, Present, and Future Perspectives from Worldwide H3 Experts. The Third Histamine Receptor: From Discovery to Clinics, a Long- Lasting Love Story at INSERM and Bioprojet. Histamine as a Neurotransmitter. THE THIRD HISTAMINE RECEPTOR. Phylogeny, Gene Structure, Expression, and Signaling. Drug Discovery: From Hits to Clinical Candidates. Peripheral Actions and Therapeutic Potential in Periphery. THERAPEUTIC POTENTIAL IN CENTRAL NERVOUS SYSTEM DISORDERS. Cognitive Functions, Attention-Deficit Hyperactivity Disorders, and Alzheimer's Disease. Sleep Disorders. Obesity. Epilepsy. Schizophrenia. Other Central Nervous System Disorders.
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