This new edition of Medical Immunology provides a brief clinical review of human response to infection. Emphasizing on clinical applications, methodological advances, immunological diseases,and innovative interventions, this guide navigates readers through technologies and demonstrates their implementation in daily clinical practice of immunology.

Introduction. Leukocytes and lymphoid tissues: The framework of the immune system. Major histocompatibility complex. Adaptive immune response: Antigens, lymphocytes, and accessory cells. Immunoglobulins: Structure and diversity. Immunoglobulins: Metabolism and biological properties. Genetics of immunoglobulins: Ontogenic, biological, and clinical implications. Antigen-antibody reactions. The complement system in health and disease. Monocyte and lymphocyte membrane markers: Ontogeny and clinical significance. Cell-mediated immunity. Adaptive humoral immunity and immunoprophylaxis. Phagocytic cells and their functions. Anti-infectious innate and adaptive immune responses. Diagnostic applications of immunology. Tolerance and autoimmunity. Organ-specific autoimmune diseases. Systemic lupus erythematosus. Rheumatoid arthritis. Overview of hypersensitivity. IgE-mediated (immediate) hypersensitivity. Immunohematology. Pathogenic role of antigen-antibody complexes. Immune system modulators. Transplantation immunology. Tumor immunology. Lymphocyte and plasma cell malignancies. Diagnosis of immune deficiency diseases. Primary immunodeficiency diseases. AIDS and other acquired immunodeficiencies