This unique book presents an approach to viewing trauma. It examines the cellular consequences of trauma at a molecular level and provides new insights into the treatment of traumatic injury, based on cellular responses. The current of trauma research is reviewed, previously unpublished information on the topic is presented, and research directions are included.

MECHANISMS OF LETHAL CELL INJURY -- Chapter 1 -- Models of Toxicity Screening Using Cultured Cells /Roberta L. Grant and Daniel Acosta, Jr. -- Chapter 2 -- Apoptosis: Cellular Signaling and Molecular Mechanisms /Rosemary B. Evans and John A. Cidlowski -- Chapter 3 -- Role of Mitochondrial Injury during Oxidative Injury to Hepatocytes: Evidence of a Mitochondrial Permeability Transition by Laser Scanning Confocal Microscopy /Anna-Liisa Nieminen, Roberto Imberti, Alice K. Saylor, Samuel A. Tesfai, Brian Herman, and John J. Lemasters -- CYTOPROTECTIVE STRATEGIES -- Chapter 4 -- Glycine Cytoprotection and Inhibition of Nonlysosomal Calcium-Dependent Proteolysis during Anoxic Injury of Rat Hepatocytes /J. Christopher Nichols, Rolland C. Dickson, Steven F. Bronk, and Gregory J. Gores -- Chapter 5 -- Di-Calciphor-Dependent Protection against Cell Death due to Mitochondrial Failure /Dean P. Jones -- Chapter 6 -- Role of the Mitochondrial ATPase Inhibitor, IF1? in Cytoprotection during Ischemia in Slow and Fast Heart-Rate Hearts /William Rouslin and Charles W. Broge -- Chapter 7 -- The Discovery and Pharmacology of Tirilazad Mesylate /John M. McCall -- Chapter 8 -- The Role of Neutrophils and Reactive Oxygen Metabolites in Reperfusion Injury /Barbara J. Zimmerman and D. Neil Granger -- Chapter 9 -- The Inflammatory Response after Hepatic Ischemia /Reperfusion /Hartmut Jaeschke -- Chapter 10 -- The pH Paradox in Reperfusion Injury to Heart Cells /John J. Lemasters, John M. Bond, Ian S. Harper, Enrique Chacon, Hisayuki Ohata, Brian Herman, and Wayne E. Cascio -- Chapter 11 -- Pathophysiology of Spinal Cord Injury in a Rat Model of Decompression Sickness /Louis Marzella -- STRESS RESPONSE AND WOUND HEALING Chapter 12 -- The Stress Response and Stress Proteins /Martin E. Feder, Dawn A. Parsell, and Susan L. Lindquist -- Chapter 13 -- Cross Talk between Heat Shock and Oxidative Stress Inducible Genes during Myocardial Adaptation to Ischemia /Dipak K. Das and Nilanjana Maulik -- Chapter 14 -- Alteration in Cell Cycle Control Factors and the Induction of Oxygen-Regulated Proteins by Hypoxic Stress /Harold C. Smith, Robert L. Howell, and John W. Ludlow -- Chapter 15 -- Stress Proteins in Renal Ischemia /Shirley Hilden -- Chapter 16 -- Human Keratinocyte Migration Involves Extracellular Matrix and Soluble Factors /David T. Woodley, John D. Chen, Elizabeth Shim, Janice P. Kim, Jean-Christophe Lapiere, and Christina Peavey -- Chapter 17 -- Endothelial Cell Signaling during Wound Healing /Lewis H. Romer -- PRESERVATION OF CELLS AND ORGANS Chapter 18 -- Development and Optimization of Preservation Solutions /James H. Southard -- Chapter 19 -- Hypoxia, Free Radicals, and Reperfusion Injury Following Cold Storage and Reperfusion of Livers for Transplantation /Ronald G. Thurman, Wenshi Gao, Henry D. Connor, Sigrid Bachmann, Robert T. Currin, Ronald P. Mason, and John J. Lemasters -- Chapter 20 -- Cellular Injury Associated with Organ Cryopreservation: Chemical Toxicity and Cooling Injury /Gregory M. Fahy, Carla da Mouta, Latchezar Tsonev, Bijan S. Khirabadi, Patrick Mehl, and Harold T. Meryman -- Index.