This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery systems.

OverviewHuman Gene Therapy: The Initial Concepts, W. French AndersonDiscovering Genes That Cause Disease, Francis S. CollinsDelivering Genes to Human LungsAdenoviral Vectors for Gene Therapy of Inherited and Acquired Disorders of the Lung, David T. Curiel and Robert I. Garver, Jr.Adeno-Associated Virus-Based Delivery Systems, Pamela L. ZeitlinCellular Responses to Adenovirus Entry, Susanna Chiocca and Matthew CottonCatonic Lipid-Based Gene Delivery: An Update, Xiang GaoLiposome/Viral Hybrid Gene Delivery Systems, Arlene A. StecenkoGene Therapy in the Lung: The Next GenerationManipulating the Intracellular Trafficking of Nucleic Acids, Kathleen E. B. Meyer, Lisa S. Uyechi, and Francis C. Szoka, Jr.Delivery of Genes Through the Lung Circulation, David M. Rodman and Elizabeth G. NabelTargeting Gene Expression to the Lung, Jeffrey A. Whitsett and Stephan W. GlasserStrategies to Accomplish Targeted Gene Delivery Employing Tropism-Modified Adenoviral Vectors, Joanne T. Douglas and David T. CurielDisease-Directed Gene TherapyToward Correction of the Genetic Defect in Cystic Fibrosis, Larry G. Johnson and Richard C. BoucherCorrection of the Genetic Defect in Alpha-1 Antitrypsin Deficiency by Somatic Gene Therapy, Randy C. Eisensmith and Savio L. C. WooGene Therapy for Chronic Inflammatory Diseases of the Lungs, Angelo E. CanonicoGene Therapy for Acute Diseases of the Lungs, Kenneth L. BrighamGene Therapy for Lung Cancer, Choon-Taek Lee and David P. CarboneEpilogueThe Regulatory Process and Gene Therapy, Suzanne EpsteinSome Issues Affecting Progress Toward Human Gene Therapy and Potential Application to the Lung, Theodore Friedmann