Bone marrow transplantation has emerged as a major form of treatment for a broad range of human diseases. Marrow transplantation has many unique biologic features and its principles differ markedly from the transplantation of solid organs. This volume overviews the present status of bone marrow transplantation and summarizes recent progress and controversies. Ad­ vances in defining the underlying biology of marrow transplantation are discussed. The current status of several major clinical problem areas are reviewed, including engraftment, acute and chronic graft-versus-host dis­ ease, immunodeficiency, and opportunistic infections. The therapeutic role of allogeneic and autologous bone marrow transplantation is discussed, and results are compared with alternative therapies. lX List of contributors ANASETII, CLAUDIO, M. D. , Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104 APPELBAUM, FRED, M. D. , Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104 ARMITAGE, JAMES 0. , M. D. , Department of Internal Medicine, Univer­ sity of Nebraska Medical Center, 42nd and Dewey Avenue, Omaha, Nebraska 68105 BEATIY, PATRICK G. , M. D. , Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104 BIERMAN, PHILIP J. , M. D. , Department of Internal Medicine, Univer­ sity of Nebraska Medical Center, 42nd and Dewey Avenue, Omaha, Nebraska 68105 BUTTURINI, ANNA, M. D. , Department of Pediatrics, University of Parma School of Medicine, Parma, Italy CHAMPLIN, RICHARD, M. D.

Bone Marrow Transplantation.- 1. Bone Marrow Transplantation: Introduction and Overview.- 2. Engraftment of T-Cell-Depleted Bone Marrow in Murine Models for Allogeneic Bone Marrow Transplantation.- 3. Recapitulation of Immune Ontogeny: A Vital Component for the Success of Bone Marrow Transplantation.- 4. Acute Graft-Versus-Host Disease.- 5. Chronic Graft-Versus-Host Disease.- 6. T-Cell Depletion for Bone Marrow Transplantation: Effects on Graft Rejection, Graft-Versus-Host Disease, Graft-Versus-Leukemia, and Survival.- 7. Cytomegalovirus Infection and Interstitial Pneumonia after Bone Marrow Transplantation.- 8. Selection of Marrow Donors for Patients Lacking an HLA Identical Sibling.- 9. Therapeutic Use of Hematopoietic Growth Factors in Bone Marrow Transplantation.- Applications of Bone Marrow Transplantation.- 10. Bone Marrow Transplantation for Immunodeficiency and Genetic Diseases.- 11. Bone Marrow Transplantation for Aplastic Anemia: Recent Advances and Comparisons with Alternative Therapies.- 12. Bone Marrow Transplantation for Acute Nonlymphocytic Leukemia (ANL).- 13. Bone Marrow Transplantation in Acute Lymphoblastic Leukemia.- 14. Therapy of Chronic Myelogenous Leukemia with Bone Marrow Transplantation.- 15. Bone Marrow Transplantation for Hodgkin's Disease, Non-Hodgkin's Lymphoma, and Multiple Myeloma.- 16. Bone Marrow Transplantation for Solid Tumors in Pediatrics.- 17. Role of Bone Marrow Transplantation as Treatment for Victims of Nuclear Accidents.