Finally, there is a dependable guide to transmyocardial laserrevasculariztion (TMR). In this groundbreaking volume, clinicianswho pioneered the use of this innovative treatment share theirinsights on the indications, results, mechanisms, and limitationsof the technique.Under the careful editorial guidance of Drs. Bridges, Horvath,and Chiu, contributing authors explain:* * the evolution, science, rationale, and limitations forTMR* how to select suitable candidates* anesthetic considerations and the role of transesophagealecho* TMR as a sole or combination therapyWhether you are already practicing TMR or contemplating itsaddition to your therapeutic armamentarium, this concise referencewill answer all your questions about this important newprocedure.

List of Contrbutors.Preface.1 Scientific and Historic Precedents.(OH Frazier, Marianne Bergheim, and Kamuran A.Kadipasaoglu).2 Laser-tissue Interaction.(E. Duco Jansen and Peter Whittaker).3 The biology of Laser-Tissue Interactions: in Vivo Comparisonsand Consequences. (Peter Whittaker and E. Duco Jansen).4 Histopathologic Effects of Transmyocardial LaserRevascularization on Myocardium: Assessment of Channel Patency.(Kamuran A. Kadipasaoglu, Egemen Tuzun, and OH Frazier).5 Animal Models of Acute and Chronic Coronary Ischemia: Effectsof TMR on Perfusion and Left Ventricular Function.(G. Chad Hughes and James E. Lowe).6 Selection Criteria for Sole Therapy and Adjunctive Therapy inCombination with Coronary Artery Bypass Graft Surgery.(Charles R. Bridges and Kapil Gopal).7 Results of Prospective Randomized Trials.(Keith B. Allen and Keith A Horvath).8 Combination Therapy with Coronary Artery Bypass Grafting.(Kapil Gopal and Charles R. Bridges).9 Operative Techniques of Transmyocardial LaserRevascularization.(Keith A. Horvath).10 The Open Channel Hypothesis for TransmyocardialRevascularization: a Re-examination. (Peter Whittaker and Chad E.Darling).11 Mechanisms of TMR: Angiogenesis. (Marc P Pelletier, VarunKapila, and Ray CJ Chiu).12 Myocardial Sinusoids and Non-compaction: Embryology andRelevance to the Adult Coronary Circulation. (Ray C.J. Chiu,Stephen J. Korkola, and Kevin Lachapelle).13 Remodeling of the Intrinsic Cardiac Nervous System FollowingChronic Transmyocardial Laser Therapy. (J. Andrew Armour).Index