Proven and tested guidelines for designing ideal labs for scientific investigationsNow in its Fourth Edition, Guidelines for Laboratory Design continues to enable readers to design labs that make it possible to conduct scientific investigations in a safe and healthy environment. The book brings together all the professionals who are critical to a successful lab design, discussing the roles of architects, engineers, health and safety professionals, and laboratory researchers. It provides the design team with the information needed to ask the right questions and then determine the best design, while complying with current regulations and best practices.Guidelines for Laboratory Design features concise, straightforward advice organized in an easy-to-use format that facilitates the design of safe, efficient laboratories. Divided into five sections, the book records some of the most important discoveries and achievements in:* Part IA, Common Elements of Laboratory Design, sets forth technical specifications that apply to most laboratory buildings and modules* Part IB, Common Elements of Renovations, offers general design principles for the renovation and modernization of existing labs* Part II, Design Guidelines for a Number of Commonly Used Laboratories, explains specifications, best practices, and guidelines for nineteen types of laboratories, with three new chapters covering nanotechnology, engineering, and autopsy labs* Part III, Laboratory Support Services, addresses design issues for imaging facilities, support shops, hazardous waste facilities, and laboratory storerooms* Part IV, HVAC Systems, explains how to heat, cool, and ventilate labs with an eye towards energy conservation* Part V, Administrative Procedures, deals with bidding procedures, final acceptance inspections, and sustainabilityThe final part of the book features five appendices filled with commonly needed data and reference materials.This Fourth Edition is indispensable for all laboratory design teams, whether constructing a new laboratory or renovating an old facility to meet new objectives.

FOREWORD xvPREFACE xviiACKNOWLEDGMENTS xixABOUT THE AUTHORS xxiABBREVIATIONS xxiiiUNITS xxvORGANIZATIONS REFERENCED xxviiINTRODUCTION xxixHow to Use This Book, xxxBook Organization, xxxiComputational Fluid Dynamics, xxxiiiPART IA COMMON ELEMENTS OF LABORATORY DESIGN 11 Building Considerations 31.1 Guiding Concepts, 31.2 Building Layout, 31.3 Guiding Principles for Building Heating, Ventilating, and Air-Conditioning Systems, 441.4 Guiding Concepts for Laboratory Building Loss Prevention, Industrial Hygiene, and Personal Safety, 511.5 Miscellaneous Services, 562 Laboratory Considerations 65PART IB COMMON ELEMENTS OF RENOVATIONS 1093 Renovations: Building Considerations 1233.1 Guiding Concepts, 1233.2 Building Layout, 1253.3 Heating, Ventilating, and Air-Conditioning Systems, 1293.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 1333.5 Miscellaneous Services, 1344 Renovations: Laboratory Considerations 1364.1 Guiding Concepts, 1364.2 Laboratory Layout, 1374.3 Heating, Ventilating, and Air-Conditioning Systems, 1384.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 138PART II DESIGN GUIDELINES FOR A NUMBER OF COMMONLY USED LABORATORIES 1415 General or Analytical Chemistry Laboratory 1435.1 Description, 1435.2 Laboratory Layout, 1445.3 Heating, Ventilating, and Air-Conditioning, 1465.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 1495.5 Special Requirements, 1496 High-Toxicity Laboratory 1506.1 Description, 1506.2 Laboratory Layout, 1516.3 Heating, Ventilating, and Air-Conditioning, 1536.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 1546.5 Special Requirements, 1557 Nanotechnology Laboratories 1567.1 Description, 1567.2 Laboratory Layout, 1567.3 Heating, Ventilating, and Air-Conditioning, 1577.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 1588 Engineering Laboratories 1608.1 Description, 1608.2 Engineering Disciplines and Some of Their Most Common Laboratory Types, 1608.3 Wind Tunnel Laboratory, 1618.4 Jet and Rocket Propulsion Laboratory, 1628.5 Hydraulics Laboratory, 1648.6 Material Analysis and Testing Laboratory, 1658.7 Electrical Circuits, Motors, and Generators Laboratory, 1658.8 Foundry Laboratory, 1678.9 Internal Combustion and Gas Turbine Engine Laboratory, 1699 Pilot Plant: Chemical, Engineering, and Biological 1739.1 Description, 1739.2 Pilot Plant Layout, 1749.3 Heating, Ventilating, and Air-Conditioning, 1749.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 1759.5 Special Requirements, 17510 Physics Laboratory 17710.1 Description, 17710.2 Laboratory Layout, 17810.3 Heating, Ventilating, and Air-Conditioning, 17910.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 17910.5 Special Requirements, 18111 Controlled Environment Room: Hot or Cold 18211.1 Description, 18211.2 Laboratory Layout, 18311.3 Heating, Ventilating, and Air-Conditioning, 18311.4 Loss Prevention, 18511.5 Special Requirements, 18512 High-Pressure Laboratory 18712.1 Description, 18712.2 Laboratory Layout, 18812.3 Heating, Ventilating, and Air-Conditioning, 18812.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 18912.5 Special Requirements, 18913 Radiation Laboratory 19013.1 Description, 19013.2 Laboratory Layout, 19113.3 Heating, Ventilating, and Air-Conditioning, 19413.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 19513.5 Special Considerations, 19514 Biosafety Laboratory 19614.1 Description, 19614.2 Laboratory Layout, 20214.3 Heating, Ventilating, and Air-Conditioning, 21214.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 21314.5 Special Requirements, 21315 Clinical Laboratories 21615.1 Description, 21615.2 Laboratory Layout, 21815.3 Heating, Ventilating, and Air-Conditioning, 22215.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 22316 Teaching Laboratory 22716.1 Description, 22716.2 Laboratory Layout, 22816.3 Heating, Ventilating, and Air-Conditioning, 23416.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 23517 Gross Anatomy Laboratory 23817.1 Description, 23817.2 Laboratory Layout, 23917.3 Heating, Ventilating, and Air-Conditioning, 24317.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 24417.5 Security, 24518 Pathology Laboratory 24618.1 Description, 24618.2 Laboratory Layout, 24918.3 Heating, Ventilating, and Air-Conditioning, 25118.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 25118.5 Special Requirements, 25219 Autopsy Laboratory 25319.1 Description, 25319.2 Laboratory Layout, 25519.3 Heating, Ventilating, and Air-Conditioning, 26019.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 26120 Morgue Facility 26220.1 Description, 26220.2 Laboratory Layout, 26520.3 Heating, Ventilating, and Air-Conditioning, 26920.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 26921 Open or Team Research Laboratory 27121.1 Description, 27121.2 Laboratory Layout, 27221.3 Heating, Ventilating, and Air-Conditioning, 27521.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 27521.5 Special Considerations, 27622 Animal Research Laboratory 27722.1 Description, 27722.2 Laboratory Layout, 27922.3 Heating, Ventilating, and Air-Conditioning, 29222.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 29622.5 Special Requirements, 29723 Microelectronics and Cleanroom Laboratories 29923.1 Description, 29923.2 Laboratory Layout, 30323.3 Heating, Ventilating, and Air Conditioning, 30723.4 Loss Prevention, Industrial Hygiene, and Personnel Safety, 31023.5 Special Requirements, 31223.6 Renovations, 31424 Printmaking Studio 31524.1 Description, 31524.2 Print Studio Layout, 31724.3 Heating, Ventilating, and Air-Conditioning, 31824.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 321PART III LABORATORY SUPPORT SERVICES 32525 Imaging and Photographic Facilities 32725.1 Introduction, 32725.2 Photographic And Imaging Facility Layouts, 33125.3 Heating, Ventilating, and Air-Conditioning, 33425.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 33625.5 Special Requirements, 33726 Support Shops 33926.1 Description, 33926.2 Layout, 34026.3 Heating, Ventilating, and Air-Conditioning, 34426.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 34626.5 Special Requirements, 34627 Hazardous Chemical, Radioactive, and Biological Waste-Handling Rooms 34827.1 Guiding Concepts, 34827.2 Layout, 35127.3 Heating, Ventilating, and Air-Conditioning, 35627.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 35827.5 Special Requirements, 35828 Laboratory Storerooms 36028.1 Description, 36028.2 Layout, 36328.3 Heating, Ventilating, and Air-Conditioning, 36628.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 36728.5 Special Requirements, 368PART IV HVAC SYSTEMS 36929 HVAC Systems 37129.1 Description, 37129.2 Air-Conditioning Systems, 37129.3 HVAC System Design and Description, 37629.4 System Descriptions and Strategies, 37729.5 Humidification and Dehumidification, 38629.6 Space Pressure Control, 38929.7 Automatic Control System, 39130 Fans 39230.1 Fan Terminology, 39230.2 Exhaust Fan Specifications, 39330.3 Atmospheric Dispersion, 39430.4 Fan Laws, 39430.5 Fan Selection, 39530.6 Fan Performance, 39631 Air Cleaning 39731.1 Introduction, 39731.2 Air-Cleaning Equipment for Laboratories, 39832 Laboratory Hoods and Other Exhaust Air Contaminant-Capture Facilities and Equipment 40432.1 Introduction, 40432.2 Conventional Bypass Chemical Fume Hoods, 40532.3 Auxiliary Air Chemical Fume Hoods, 40932.4 Perchloric Acid Fume Hoods, 41132.5 Hoods for Work With Radioactive Materials, 41132.6 Variable Air-Volume Hoods, 41132.7 High-Performance Hoods, 41232.8 Gloveboxes, 41232.9 Biological Safety Cabinets, 41332.10 Capture (Exterior) Hoods, 41632.11 Ductless Hoods, 41632.12 Performance Tests, 42033 Exhaust Air Ducts and Accessories 42233.1 Introduction, 42233.2 Exhust Duct Considerations, 42333.3 Exhust System Classification, 42433.4 Duct Accessories, 42434 Variable-Air-Volume Systems 42634.1 Introduction, 42634.2 VAV Hoods, 42734.3 Good Design Practices for Vav Systems, 42834.4 Variable-Volume Exhaust System Operational Concept, 42834.5 VAV System Controls and Components, 42934.6 VAV System Fan Controls and Components, 43134.7 VAV System Duct Configurations, 43435 Energy Conservation 43635.1 Introduction, 43635.2 Recent Trends, 43735.3 Exhaust Ventilation for Contamination Control, 44035.4 Lighting, 44835.5 Thermal Insulation, 44835.6 Humidity Control, 44835.7 Evaporative Cooling, 44935.8 Water Conservation, 44935.9 Efficient Operating Strategies, 449PART V ADMINISTRATIVE PROCEDURES 45136 Project Execution and Bidding Procedures 45336.1 Guiding Concepts, 45336.2 Implementation, 45436.3 Bid Form, 45636.4 Contract, 45736.5 Change Orders, 45736.6 Construction Inspections, 45836.7 Punch List, 45836.8 Additional Testing and Acceptance, 45836.9 Beneficial Occupancy, 45936.10 Final Acceptance and Commissioning, 45937 Commissioning and Final Acceptance Criteria 46037.1 Guiding Concepts, 46037.2 Design, Construction, and Preoccupancy Checklists, 46037.3 Heating, Ventilating, and Air-Conditioning, 46237.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 46637.5 Project Commissioning, 46738 Sustainable Laboratory Design 47138.1 Introduction, 47138.2 Laboratory Construction Materials, 47238.3 Heating, Ventilating, and Air-Conditioning, 47438.4 Loss Prevention, Industrial Hygiene, and Personal Safety, 47738.5 Miscellaneous Services, 47738.6 Lighting, 47838.7 Submetering, 47938.8 Additional Background Material, 479PART VI APPENDIXES 481Appendix A Emergency Showers 483Appendix B Emergency Eyewash Units 485Appendix C Signs 486Appendix D Stack Design 489Appendix E Matrix of Building Consideration for SpecificLaboratory Types 495REFERENCES 500INDEX 509