The definitive guide to peptidomics- a hands-on lab referenceThe first truly comprehensive book about peptidomics for proteinand peptide analysis, this reference provides a detaileddescription of the hows and whys of peptidomics and how thetechniques have evolved. With chapters contributed by leadingexperts, it covers naturally occurring peptides, peptidomicsmethods and new developments, and the peptidomics approach tobiomarker discovery. Explaining both the principles and theapplications, Peptidomics: Methods and Applications:* Features examples of applications in diverse fields, includingpharmaceutical science, toxicity biomarkers, and neuroscience* Details the successful peptidomic analyses of biological materialranging from plants to mammals* Describes a cross section of analytical techniques, includingtraditional methodologies, emerging trends, and new techniques forhigh throughput approachesAn enlightening reference for experienced professionals, this bookis sufficiently detailed to serve as a step-by-step guide forbeginning researchers and an excellent resource for students takingbiotechnology and proteomics courses. It is an invaluable referencefor protein chemists and biochemists, professionals and researchersin drug and biopharmaceutical development, analytical andbioanalytical chemists, toxicologists, and others.

SECTION 1: STUDIES OF NATURALLY OCCURRING PEPTIDES.Chapter 1: Analysis of the peptidomes of amphibian skin granulargland secretions - an integrated functional genomic strategy (ChrisShaw, and Tianbao Chen).Chapter 2: A short history of insect (neuro)peptidomics - Apersonal story of the birth and youth of an excellent model forstudying peptidome biology (Peter D.E.M. Verhaert, Martijn W.H.Pinkse, Maria C. Prieto-Conaway, and Markus Kellmann).Chapter 3: Peptidomics of short linear cytolytic peptides fromspider venom (Sergey A. Kozlov, Alexander A. Vassilevski, andEugene V. Grishin).Chapter 4: Molecular cloning approaches to peptidomics: theidentification of novel cDNAs encoding neurotoxin-like peptidepools (Zhensheng Pan, Richard Barry, and Mikhail Soloviev).Chapter 5: Wheat antimicrobial peptides (Tatyana I. Odintsova,and Tsezi A. Egorov).Chapter 6: Immunopeptidomics: Applications to dissect immuneresponses through proteomic-based approaches (Ernesto Oviedo-Orta,and Alexandra Bermudez-Fajardo).Chapter 7: Strategies for reliable and improved identificationof peptides (Karl Skuld, Maria Folth, Marcus Svensson, AnnaNilsson, Per Svenningsson, and Per E. Andrun).SECTION 2: PEPTIDOMICS METHODS AND NEW DEVELOPMENTS.Chapter 8: Peptidomics approach to proteomics (Petra Zarbig, andHarald Mischak).Chapter 9: The importance of sample handling in neuropeptidomics(Karl Skuld, Marcus Svensson, Anna Nilsson, Maria Folth, PerSvenningsson, and Per E. Andrun).Chapter 10: Affinity peptidomics and protein microarrays:application to forensics and biometrics (Julian Bailes, and MikhailSoloviev).Chapter 11: Selective depletion and enrichment methods for theanalysis of protein and peptide pools (Paul Finch, and MikhailSoloviev).Chapter 12: Detection of target peptides in foods and feeds bymass spectrometry (Mireia Fernandez Ocaca).Chapter 13: Quantification of Polypeptides by Mass Spectrometry(Pedro R. Cutillas).SECTION 3: PEPTIDOMICS APPROACH TO BIOMARKERDISCOVERY.Chapter 14: Biomarker discovery (Petra Zarbig, and HaraldMischak).Chapter 15: Can peptidomics provide a useful approach for theidentification of biomarkers of toxicological exposure or effect(Helen Griffiths)?Chapter 16: Peptidomics in Neuroendocrine research: aCaenorhabditis elegans and Mus musculus study (Kurt Boonen, StevenJ. Husson, Geert Baggerman, Anja Cerstiaens, Walter Luyten, andLiliane Schoofs).CONCLUSION.Chapter 17: Peptidomics and Biology: two scientific disciplinesdriving each other (Chris Shaw, and Peter D.E.M. Verhaert).