This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated.Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title:* descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific* discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.

Symposiumon Genomics of autoimmunity, held at the NovartisFoundation, London, 22-24 June, 2004.Editors: Gregory Bock (Organizer) and Jamie Goode.This symposium is based on a proposal by Abul Abbas, DavidHafler and John Rioux.Abbul Abbas: Chair's introduction.Mark Daly: Patterns of genetic variation in humans andmice.Discussion.David B. Goldstein: Haplotype tagging inpharmacogenetics.Discussion.Simon J. Foote, Justin P. Rubio, Melanie Bahlo, Trevor J.Kilpatrick, Terence P. Speed, Jim Stankovich, Rachel Burfoot,Helmut Butzkueven, Laura Johnson, Chris Wilkinson, Bruce Taylor,Michele Sale, Ingrid A. F. van derMei, Joanne L. Dickinson andPatricia Groom: Multiple sclerosis: a haplotype associationstudy.Discussion.Juha Kere: Mapping genes for asthma and psoriasis.Discussion.Linda S. Wicker, Carolyn L. Moule, Heather Fraser, CarlosPenha-Goncalves, Dan Rainbow, Valerie E. S. Garner, GiselleChamberlain, Kara Hunter, Sarah Howlett, Jan Clark, AndreaGonzalez-Munoz, Anne Marie Cumiskey, Paul Ti¡en, JoannaHowson, Barry Healy, Luc J. Smink, Amanda Kingsnorth, Paul A.Lyons, Simon Gregory, Jane Rogers, John A.Todd and Laurence B.Peterson: Natural genetic variants influencing type 1 diabetesin humans and in the NOD mouse.Discussion.Srividya Subramanian and Edward K. Wakeland: The importanceof epistatic interactions in the development ofautoimmunity.Discussion.Timothy J. Vyse, Angela Richardson, EmilyWalsh, Lisa Farwell,MarkJ. Daly, Cox Terhorst and John D. Rioux: Mapping autoimmunedisease genes in humans: lessons from IBD and SLE.Discussion.Cisca Wijmenga and Martin C. Wapenaar: A combined geneticsand genomics approach to unravelling molecular pathways in coeliacdisease.Discussion.Timothy W. Behrens, Robert R. Graham, Chieko Kyogoku, Emily C.Baechler, Paula S. Ramos, Clarence Gillett, Jason Bauer, Ward A.Ortmann, Keli L. Hippen, Erik Peterson, Carl D. Langefeld, KathyL.Moser, Patrick M. Ga¡neyand Peter K. Gregersen: Progresstowards understanding the genetic pathogenesis of systemic lupuserythematosus.Discussion.Vigo Heissmeyer, Fernando Maciä n, Rajat Varma, Sin-HyeogIm, Francisco García-Cozar, Heidi F.Horton, Michael C. Byrne,Stefan Feske, K. Venuprasad, Hua Gu, Yun-Cai Liu, Michael L. Dustinand Anjana Rao: A molecular dissection of lymphocyteunresponsiveness induced by sustained calcium signaling.Discussion.Adrian Liston and Christopher C. Goodnow: Genetic lesions inthymicTcell clonal deletion and thresholds forautoimmunity.Discussion.Lalitha Vijayakrishnan, Jacqueline M. Slavik, Zsolt Illés,Dan Rainbow, Laurence B. Peterson, Arlene S. Sharpe, Linda S.Wickerand, Vijay K. Kuchroo: An autoimmune disease-associatedCTLA4 splice variant lacking the B7 binding domain signalsnegatively in Tcells.Discussion.Adrian Ting, Stefan Lichtenthaler, Ramnik Xavier, Soon-Young Na,Shahrooz Rabizadeh,TaraHolmes and Brian Seed: Large-scalescreens for cDNAs with in vivo activity.Discussion.Jenny Ting: Genomic mining of new genes and pathways ininnate and adaptive Immunity.Discussion.Index of contributors.Subject index.