Therapies for Treatment-Resistant Depression: Neuropharmacology and Neurostimulation provides readers with an authoritative, comprehensive and targeted treatment guide. The first section reviews the essential knowledge and methods of clinical neuroscience and neuropsychopharmacological techniques as they apply to novel treatment discovery for depression. This is followed by detailed chapters on ketamine, esketamine, other glutamate modulators in development, GABA modulators, neuropeptides, anti-inflammatory agents, and other classes of novel therapeutics under study for TRD and related mood disorders. The last section consists of a set of chapters of special interest that includes current and future research directions, development of psilocybin-based interventions and other psychedelic compounds currently under study for TRD and advances in biomarker-guided and personalized treatment. Edited by world renowned experts in the field, this book is the ultimate resource for researchers and clinicians.

1. Introduction 2. Treatment-Resistant Depression: Definitions, Epidemiology and Public Health Burden 3. Overview of Current Pharmacotherapy Options and Treatment Algorithms for TRD 4. From Novel Molecules to New Therapeutics for Mood Disorders: Pathways of Drug Discovery 5. Neuroimaging and Brain Based Biomarkers in Treatment-Resistant Depression 6. Inflammation and Peripheral Biomarkers in Treatment-Resistant Depression 7. Role of the Glutamate System in Treatment-Resistant Depression 8. Role of the GABA System in Treatment-Resistant Depression 9. Role of the Neuropeptides and Other Neuro-active Hormones in Treatment-Resistant Depression 10. Ketamine for Treatment-Resistant Depression: Discovery and Current Directions in Research and Clinical Care 11. Safety and Monitoring of Ketamine in Clinical Care 12. Development and Efficacy of Esketamine Treatment-Resistant Depression 13. Novel Glutamate Modulators in Development for Treatment-Resistant Depression 14. Brexanolone and Other GABA Modulators for Treatment-Resistant Depression 15. Special Topics: Psilocybin and Other Psychedelic Agents in Development for TRD 16. Special Topics: Role of Biomakers in Treatment Selection for Treatment-Resistant Depression 17. Special Topics: Current and Future Role of Genetics and Genomics in Treatment-Resistant Depression