In this issue of Orthopedic Clinics, guest editors from the esteemed Campbell Clinic bring their considerable expertise to the topic of Infections. Eleven top experts discuss key concepts relating to infections to guide effective decision making. Early diagnosis and treatment are key to success, and in order to address an infection, the medical care team needs to address four fundamental questions: where is it, what is it, how severe is it, and how to treat it. The articles outlined in this issue will help physicians better understand common pathogens, identify signs of infection, and ultimately answer these fundamental questions in order to improve patient outcomes.

Current Concepts on the Clinical and Economic Impact of Periprosthetic Joint InfectionsBiofilm and How It Relates to Prosthetic Joint InfectionInnovations in the Isolation and Treatment of Biofilms in Periprosthetic Joint Infection: A Comprehensive Review of Current and Emerging Therapies in Bone and Joint Infection ManagementArticulating Spacers in Total Hip Arthroplasty: Surgical Technique and OutcomesRecurrent Periprosthetic Joint Infections: Diagnosis, Management, and OutcomesThe State of Local Antibiotic Use in Orthopedic TraumaNavigating the Enigma of Pediatric Musculoskeletal Infections: A Race Against TimeSequestration and Involucrum: Understanding Bone Necrosis and Revascularization in Pediatric OrthopedicsThe Septic Elbow Joint: Treatment Approaches for Improved Patient OutcomesDiagnostic Evaluation of Prosthetic Joint Infections of the Shoulder: What Does the Literature Say?Fingertip InfectionsManagement of the Septic Wrist: A Systematic Review of Etiology and Therapeutic StrategiesDiagnosis and Management of Infected Total Ankle ReplacementsThe Differentiation Between Infection and Acute Charcot