Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.

Provides a comprehensive, single source of authoritative information on protein/cell/tissue-biomaterial interactions

Protein Adsorption to BiomaterialsDavid R. Schmidt, Heather Waldock, and W. John Kao Investigating Protein Adsorption via Spectroscopic EllipsometryMaria F. Mora, Jennifer L. Wehmeyer, Ron Synowicki, and Carlos D. Garcia AFM Methods for Characterizing Protein Interactions with Microphase-Separated Polyurethane BiomaterialsLi-Chong Xu, Pranav Soman, Aashiish Agnihotri, Christopher A. Siedlecki Molecular Simulation of Protein-Surface InteractionsRobert A. Latour Biomolecule-Nanomaterial Interactions: Effect on Biomolecular Structure, Function, and StabilityRavindra C. Pangule, Shyam S. Bale, Dhiral A. Shah, Amit Joshi, Prashanth Asuri, Jonathan S. Dodrick, and Ravi S. Kane Phage Display as a Strategy for Designing Organic/Inorganic BiomaterialsSharon Segvich and David H. Kohn Extracellular Matrix-derived Ligand for Selective Integrin Binding to Control Cell FunctionTimothy A. Petrie and Andrés J. Garcia Ligand-functionalized Biomaterial Surfaces: Controlled Regulation of Signaling Pathways to Direct Cell DifferentiationMyung Hee Kim and Krishnendu Roy Combination of Growth Factors with ScaffoldsYoshiro Ito Cell and Tissue Interactions with Materials: The Role of Growth FactorsChristopher C. Gibson, David A. Puleo and Rena Bizios In Vitro and in Vivo Monocyte, Macrophage, Foreign Body Giant Cell and Lymphocyte Interactions with BiomaterialsJames M. Anderson Development and Differentiation of Neural Stem and Progenitor Cells on Synthetic and Biologically-based SurfacesErin N. Boote Jones, Donald S. Sakaguchi and Surya K. Mallapragada Towards osteogenic differentiation of marrow stromal cellsand in vitro production of mineralized extracellular matrix onto natural scaffoldsAna M. Martins, Catarina M. Alves, Rui L. Reis, Antonios G. Mikos, and F. Kurtis Kasper Biomimetic Nanophase Materials to Promote New Tissue Formation for Tissue Engineering ApplicationsXiaohua Liu, Ian O. Smith and Peter X. Ma Photofunctionalization of Materials to Promote Protein and Cell Interactions for Tissue Engineering ApplicationsShalu Suri, Ankur Singh, and Christine E. Schmidt Hydrogel Nanocomposites in Biology and Medicine: Applications and InteractionsNitin Satarkar, Ashley Hawkins, and J. Zach Hilt Protein and Cell Interactions with Nanophase BiomaterialsCourtney M. Creecy, David A. Puelo, and Rena Bizios Inflammatory Response to Implanted Nanostructured MaterialsKristy M. Ainslie, Rahul G. Thakar, Daniel A. Bernards, and Tejal A. Desai Collagen-I-coated Titanium Surfaces for Bone ImplantationMarco Morra, Clara Cassinelli, Giovanna Cascardo, Daniele Bollati Prevention of Post-Surgical AdhesionJohn M. Medley and Thomas D. Dziubla