The field of solid tumor oncology is changing at an astonishing rate. To learn about new developments, generate fresh research perspectives, and then integrate these advancements into clinical practice is a daunting challenge confronting all who work in the oncology arena. The onset and rapid deployment of Internet capacities worldwide has created a mileau of global and instantaneous information access. The task of staying current is - coming even more challenging, and in some ways, more difficult to accomplish. Against this information pressure backdrop, how can yet more didactic material for the already overburdened oncology physician be justified? Based on the premise that we all must remain in a learning mode if we are to remain relevant, The University of Texas M. D. Anderson Annual of Solid Tumor Oncology is designed to focus on a single disease site in each volume. It is our belief that there is an information ¿gray zone¿ that lies - tween the peer reviewed (and increasingly electronically available) individual research - port and the large comprehensive multiauthored textbook. Between these two loci there - ists an information gap that will be best served by a succinct disease site-focused volume that provides an in-depth analysis of current multimodality care for a specific solid tumor system, as well as the areas of basic, translational, and clinical research that will emerge for future clinical application.

Pancreatic Cancer defines the current standard on multimodality care: surgery, chemotherapy, immunotherapy, gene therapy, radiotherapy, and a review of the latest research and clinical trials. A must-have for surgical oncologists and general surgeons.

Epidemiology/Molecular Biology.- Molecular Epidemiology.- The Molecular Biology of Pancreatic Cancer.- Molecular Markers as a Tool for the Early Diagnosis of Pancreatic Cancer.- Cell Signaling Pathways in Pancreatic Cancer.- Epithelial Stem Cells in Pancreatic Regeneration and Neoplasia.- Inherited Pancreatic Cancer Syndromes.- Staging.- Pancreatic Cancer: Radiologic Staging.- Endoscopic Diagnosis and Staging: Endoscopic Ultrasound, Endoscopic Retrograde Cholangiopancreatography.- Laparoscopic Staging.- Surgery/Therapeutic Endoscopy/Pain Management.- Whipple Procedure: 1935 to Present.- Regional Lymph Node Dissection for Pancreatic Adenocarcinoma.- Pylorus Preservation versus Standard Pancreaticoduodenectomy: Oncologic Controversies.- Vascular Resection and Reconstruction for Localized Pancreatic Cancer.- Techniques for Biliary and Pancreatic Reconstruction After Pancreaticoduodenectomy.- Transduodenal Local Resection for Periampullary Neoplasms.- Distal Pancreatectomy for Pancreatic Cancer.- Risks of Perioperative Mortality with Pancreaticoduodenectomy.- Endoscopic Palliation for Locally Advanced and Metastatic Disease: Biliary and Duodenal Stents.- Celiac Plexus Block Versus Systemic Opioid Medication in the Management of Pancreatic Cancer Pain.- Multimodality Therapy.- Postoperative Adjuvant Therapy: Past, Present, and Future Trial Development.- Preoperative (Neoadjuvant) Therapy for Resectable Adenocarcinoma of the Pancreas.- European Adjuvant Trials.- Adjuvant Regional Infusion Therapy.- Adjuvant Regional Infusion Therapy.- Adjuvant Regional Infusion Therapy.- Intraoperative Radiation for Pancreatic Cancer.- Conformal Radiation Therapy in Pancreatic Cancer.- Radiation Sensitizers, Fractionation Schedules, and Future Clinical Trials.- Cytotoxic Chemotherapy for Pancreatic Cancer: Past, Present, and Future.- Emerging Therapies.- Animal Models of Pancreatic Adenocarcinoma.- Strategies for Gene Therapy.- Photodynamic Therapy and Endoscopic Ultrasound-Guided Therapy for Pancreatic Cancer.- Vaccine Therapy for Pancreatic Cancer.- Antiangiogenic Strategies in Pancreatic Cancer.- Role of Matrix Metalloproteinase Inhibition in the Treatment of Pancreatic Cancer.- Regulation of Pancreatic Cancer Growth by Gastrointestinal Hormones: A Clinically Useful Strategy?.- Farnesyltransferase Inhibitors: Biological Considerations for Future Therapeutics.- Novel Therapeutic Targets for Drug Development.