Almost four decades of innovative and intensive research on Alzheimer's disease (AD) have brought major advances in our understanding of its pathogenesis, while improving tools for diagnosis and developing strategies for its treatment. This research has helped build a solid foundation of knowledge in the neurosciences and biological basis of AD and AD-related neurological disorders. Current Hypotheses and Research Milestones in Alzheimer's Disease contains 20 seminal chapters by authors with varying views on the neuroanatomical, neuropathological, neuropsychological, neurological, and molecular aspects of AD, and offers the scientific background and insightful hypotheses needed to create an effective therapy for this devastating disease. These chapters grew out of "Current Hypothesis on Alzheimer's Disease," held in Viña del Mar, Chile, in November of 2007. Participants included the world's leading Alzheimer's researchers, whose work have illuminated AD investigations during the past few decades.

"Almost four decades of innovative and intensive research on Alzheimer's disease (AD) have brought major advances in our understanding of its pathogenesis, improved tools for diagnosis, and strategies for its treatment. This research has helped build a solid foundation of knowledge in the neurosciences and biological basis of AD and AD-related neurological disorders. Scientific background and insightful hypotheses are of major relevance in order to approach to an effective therapy for this devastating disease.Current Hypotheses and Research Milestones in Alzheimer's Disease contains 20 seminal chapters by authors with varying views on the neuroanatomical, neuropathological, neuropsychological, neurological, and molecular aspects of AD. These chapters grew out of "Current Hypothesis on Alzheimer's Disease", held in Viña del Mar, Chile, in November of 2007. Participants included the world's leading Alzheimer's researchers, whose work has illuminated AD investigations during the past few decades.Students, academics and medical professionals will find this text an invaluable addition to the study of this important subject."

Amyloid-ß: General Aspects.- Role of A? Degrading Enzymes in Synaptic Plasticity and Neurogenesis in Alzheimer's Disease.- Pore-Forming Neurotoxin-Like Mechanism for A? Oligomer-Induced Synaptic Failure.- Interventions in Aging and Neurodegenerative Disease: Effects on Adult StemCells.- Neuronal Cytoskeleton and the Tau Hypothesis.- Tau Transgenic Mouse Models in Therapeutic Development.- What Have We Learned from the Tau Hypothesis?.- Neuronal Cytoskeleton Regulation and Neurodegeneration.- Stages of Pathological Tau-Protein Processing in Alzheimer's Disease: From Soluble Aggregations to Polymerization into Insoluble Tau-PHFs.- Plasma Membrane-Associated PHF-Core Could be the Trigger for Tau Aggregation in Alzheimer's Disease.- Oxidative Stress Hypothesis.- Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer's Disease.- Neuroimmunological Hypothesis.- Inflammatory Processes Exacerbate Degenerative Neurological Disorders.- Central Nervous System Inflammation and Cholesterol Metabolism Alterations in the Pathogenesis of Alzheimer's Disease and Their Diagnostic and Therapeutic Implications.- Participation of Glial Cells in the Pathogenesis of AD: A Different View on Neuroinflammation.- Cerebrovascular Pathology and AD.- Cerebral and Cardiac Vascular Pathology in Alzheimer's Disease.- Are Amyloids Infectious?.- The Possible Link Between Herpes Simplex Virus Type 1 Infection and Neurodegeneration.- General Aspects of AD Pathogenesis.- Selective Cerebrocortical Regional, Laminar, Modular and Cellular Vulnerability and Sparing in Alzheimer's Disease: Unexploited Clues to Pathogenesis, Pathophysiology, Molecular- and Systems-Level Hypothesis Generation and Experimental Testing.- How Biochemical Pathways for Disease May be Triggered by Early-Life Events.- Biomarkers and AD.- Strategies for Alzheimer's Disease Diagnosis.- Cognitive Neurology in AD.- The Diagnosis of Dementia in Subjects with Heterogeneous Educational Levels.- Current Anti-Dementia Drugs: Hypothesis and Clinical Benefits.