This interdisciplinary book is one of the first practical guides to imaging children with PET. Heavily illustrated, the book provides the reader with key information on technical and clinical issues specific to pediatric PET imaging. Special considerations regarding radiation dosage and sedation, principles of operation, instrumentation, and nuclear medicine regulations are discussed. Subsequent sections present diseases and clinical applications of PET in pediatrics. The discussions are based an exhaustive review of pediatric PET studies by Martin Charron, MD, and a select group of leading international authorities. The scope of pathologies addressed is extensive. Applications in oncology, neurology, psychiatry and other fields are outlined. Future research applications are offered as well. The book not only covers dedicated PET imaging, but also integrates coincidence imaging, PET/CT, and PET/MR. This thorough text is a vital aid to nuclear medicine physicians, radiologists, and oncologists seeking to successfully apply recent innovations in pediatric PET imaging.

"The technique for successfully completing a PET procedure is complex and involves a knowledge of physics, pharmacy, anatomy, physiology, and the disease process; applying PET scanning to children is even more challenging and technically demanding. One cannot simply adopt the approach used for adults but instead must receive specialized training in order to master pediatric PET procedures. This one-of-a-kind, interdisciplinary book is one of the first practical guides to imaging children with PET.The text opens with a section that focuses on practical and technical issues of pediatric PET imaging, including radiation dose and sedation. Principles of operation, instrumentation, and nuclear medicine regulations are also discussed. Subsequent sections cover the clinical applications of PET in pediatrics. With contributions from leading international authorities in the field, each chapter is heavily illustrated and provides the reader with extensive coverage of the essentials of clinical PET studies in oncology and neurology, which standout as key areas for PET imaging in pediatrics. TOC:The Nuclear Imaging Technologist and the Pediatric Patient.- Common Sedation Issues in Children.- The Biological Effects of Low-level Radiation.- Dosage of Radiopharmaceuticals and Internal Dosimetry.- Pediatric PET Research Regulations.- Issues in the IRB Review of PET Scan Protocols.- Ethics of PET Research in Children.- Physics and Instrumentation in PET.- How to Image a Child by PET-CT.- Coincidence Imaging.- Brain.- Lymphoma.- Neuroblastoma.- Wilms Tumor.- Primary Bone.- Soft Tissue Sarcomas.- Other Tumors.- The Developing Brain.- Neurodevelopmental and Neuropsychiatric.- Epilepsy.- Neurotransmitter Imaging.- Cardiovascular.- Fever of Unknown.- Infection and Inflammation.- Inflammatory Bowel Disease.- Hyperinsulinism.- Part I: Noninvasive Differential Diagnosis of Hyperinsulism of Infancy.- Part II: Localization of Focal Forms of Hyperinsulinism of Infancy.- Multimodal Imaging Using PET and MRI.- Current Research Efforts.- PET-CT Atlas.- Common Artifacts on PET Imaging."

Basic Science and Practical Issues.- The Nuclear Imaging Technologist and the Pediatric Patient.- Sedation of the Pediatric Patient.- The Biologic Effects of Low-Level Radiation.- Dosage of Radiopharmaceuticals and Internal Dosimetry.- Pediatric PET Research Regulations.- Issues in the Institutional Review Board Review of PET Scan Protocols.- Ethics of PET Research in Children.- Physics and Instrumentation in PET.- How to Image a Child by PET-Computed Tomography.- Coincidence Imaging.- Oncology.- Brain Tumors.- Lymphoma.- Neuroblastoma.- Wilms' Tumor.- Primary Bone Tumors.- Soft Tissue Sarcomas.- Other Tumors.- Neurology and Psychiatry.- The Developing Brain.- Neurodevelopmental and Neuropsychiatric Disorders.- Epilepsy.- Neurotransmitter Imaging.- Other Applications.- Cardiovascular Applications.- Fever of Unknown Origin.- Infection and Inflammation.- Inflammatory Bowel Disease.- Hyperinsulinism of Infancy: Noninvasive Differential Diagnosis.- Hyperinsulinism of Infancy: Localization of Focal Forms.- Multimodal Imaging Using PET and MRI.- Current Research Efforts.- Imaging Atlas.- PET-Computed Tomography Atlas.- Common Artifacts on PET Imaging.