The International Society of Oxygen Transport to Tissue (ISOTT) was founded in 1973 to provide a forum for bioengineers, basic scientists, physiologists, and physicians to discuss new data, original theories, new interpretations of old data, and new technologies for the measurement of oxygen. At each annual meeting all posters are presented orally along with plenary lectures, and all presentations are given in a general session attended by everyone. Each meeting has had a specific focus, ranging from neonatology to physical chemistry to cancer biology. The Society has helped to build many careers, through opportunities to meet leaders in the field, and through awards made to young physicians and scientists. The Society also, through cross fertilization of ideas and scientific comradery, has inspired many breakthroughs in clinical medicine that now benefit mankind. I find myself president of the society after having been a winner of the Melvin Knisely Award for young scientists, in 1991. The 2003 meeting emphasized the role of oxygen and oxygen measurement in tumor growth, metastasis, physiology, and treatment resistance. Additionally, however, completely novel approaches to measurement of tissue oxygen were presented (notably work by Dr. Takahashi) and molecular methods for estimating tissue oxygen were evaluated. Papers discussing other aspects of oxygen measurement and pathophysiology were presented including in vivo ESR spectroscopy (notably including Dr. Swartz and colleagues), exercise physiology, organ transplant outcome (discussed by Dr. Cicco, our 2004 president), circulatory physiology, and cerebral oxygenation (notably including Dr. Chance).

"This book cover all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology. TOC:Cerebral Oxygenation during Repetitive Apnea in Newbork Piglets.- Optimal Determination of Detector Placement in Cerebral Nir Spectroscopy of Neonates Using Chemometric Techniques.- Simulation Study of Breast Tissue Hemodynamics during Pressure Perturbation.- Microvascular Oxygenation and Oxidative Stress during Postischemic Reperfusion: Po2,Ros, and No during Reperfusion.- Hypoxia, Tumor Endothelium, and Targets for Therapy.- Genetic Oxygen Sensor: Gfp As An Indicator of Intracellular Oxygenation.- Effects of Insulin And Catecholamines on Inotropy and Oxygen Uptake: Best Perfusate for Skeletal Muscles.- Adaptation to Chronic Hypoxia During Diet-Induced Ketosis.- Varied Response of Spontaneous Tumors to Antiangiogenic Agents.- Non-Invasive Measurement of Tumor Oxygenation Using Embedded Microparticulate Epr Spin Probe.- The Effects of Tumor Blood Flow and Oxygenation Modifiers on Subcutaneous Tumours as Determined by Nirs.- Hyperthermia And Hypermetabolism in Focal Cerebral Ischemia.- Variability of Cerebral Hemoglobin Concentration in Very Preterm Infants during The First 6 Hours of Life.- Computational Study on Use of Single-Point Analysis Method For Quantitating Local Cerebral Blood Flow in Mice.- Effects of Temperature on Oxygen Transport in Sheets and Spheres of Respiring Tissues.- Modeling of the Response of Pto2 in Rat Brain to Changes in Physiological Parameters.- Black Magic And Epr Oximetry: From Lab to Initial Clinical Trials.- Axial Oxygen Diffusion in The Krogh Model: Modifications to Account for Myocardial Oxygen Tension in Isolated Perfused Rat Hearts Measured by Epr Oximetry.- Differentiating Hemodynamic Compromise by The Oef Response to Acetazolamide in Occlusive Vascular Disease.- The Anomalous Einstein-Stokes Behaviour of Oxygen And Other Low Molecular Weight Diffusants.- Gut Dysoxia: Comparison of Sites to Detect Regional Gut Dysoxia.- Imaging Oxygen Pressure in The Retina of The Mouse Eye.- Fluorescence-Mediated Detection of A Heterogeneity in Highly Scattering Media.- Developing Strategies for Three-Dimensional Imaging of Oxygen Tension in The Rodent Retina.- Cerebral Pto2, Acute Hypoxia, And Volatile Anesthetics in The Rat Brain.- Rate of Change in Cerebral Oxygenation And Blood Pressure in Response to Passive Changes in Posture: A Comparison between Pure Autonomic Failure Patients And Controls.- Validation of The Cas Neonatal Nirs System by Monitoring Vv-Ecmo Patients: Preliminary Results.- Interactions between Hif-1 And Jab1: Balancinc Apoptosis And Adaptation: Outline of A Working Hypothesis.- Past, Present, And Future of Oxygen in Cancer Research.- Benzoate Hydroxylation: A Measure of Oxidative Stress In Divers.- Mitochondrial Nadh As The Bellwether of Tissue O2 Delivery.- Process Scale-Up Studies for Protein C Separation Using Imac.- Hypoxia-Induced Alterations in Hyaluronan And Hyaluronidase.- Rate of Decrease Of Po2 From An Arteriole with Arrested Flow.- Measurement Of Cmro2 in Neonates Undergoing Intensive Care Using Near Infrared Spectroscopy.- The Pathways of Oxygen in Brain I: Delivery And Metabolism of Oxygen.- The Pathways of Oxygen In Brain Ii: Competitions for Cytochrome C Oxidase And Nos Are Keys to Flow-Metabolism Coupling.- Exogenous And Endogenous Markers of Tumour Oxygenation Status: Definitive Markers of Tumour Hypoxia? The Difficulties in Comparing In Vivo Oxygen Measurements; Turning The Problems into Virtues.- Preliminary Study of Simultaneous Multi-Anticoagulant Deficiency Diagnosis by Fiber Optic Multi-Analyte Biosensor.- Circulation Time in Man From Lung to Periphery As An Indirect Index of Cardiac Output.- Factors Controlling Oxygen Utilization.- Amputation Level Viability in Critical Limb Ischaemia: Setting New Standards.- Hypoxia in Breast Cancer: Role of Blood Flow, Oxygen Diffusion Distances, And Anemia in The Development of Oxygen Depletion.- Monitoring Metabolite Gradients in The Blood, Liver, And Tumour after Induced Hyperglycemia in Rats With R3230 Flank Tumors Using Microdialysis And Bioluminescence Imaging.- Possible Protective Effects Of Tocopherol on Enhanced Induction of Reactive Oxygen Species By 2-Methoxyestradiol in Tumors.- Simultaneous Nir-Epr Spectroscopy of Rat Brain Oxygenation.- Microcirculation And Reperfusion Injury in Organ Transplantation.- Focussing on Genomic And Phenomic Correlations in Respiration Of Non-Melanotic Skin Cancers.- Protein C Production: Metal Ion/Protein Interfactil Interaction in Immobilized Metal Affinity Chromatography.- Modeling Behavior of Protein C during And after Subcutaneous Administration.- Mechanisms for Vasoconstriction And Decreased Blood Flow Following Intravenous Administration of Cell-Free Native Hemoglobin Solutions.- Author Index.- Keyword Index."

Cerebral Oxygenation During Repetitive Apnea in Newborn Piglets.- Optimal Determination of Detector Placement in Cerebral NIR Spectroscopy of Neonates Using Chemometric Techniques.- Simulation Study of Breast Tissue Hemodynamics During Pressure Perturbation.- Microvascular Oxygenation and Oxidative Stress During Postischemic Reperfusion.- Hypoxia, Tumor Endothelium, and Targets for Therapy.- Genetic Oxygen Sensor.- Effects of Insulin and Catecholamines on Inotropy and Oxygen Uptake.- Adaptation to Chronic Hypoxia During Diet-Induced Ketosis.- Varied Response of Spontaneous Tumors to Antiangiogenic Agents.- Non-Invasive Measurement of Tumor Oxygenation Using Embedded Microparticulate EPR Spin Probe.- The Effects of Tumour Blood Flow and Oxygenation Modifiers on Subcutaneous Tumours as Determined by NIRS.- Hyperthermia and Hypermetabolism in Focal Cerebral Ischemia.- Variability of Cerebral Hemoglobin Concentration in Very Preterm Infants During the First 6 Hours of Life.- Computational Study on Use of Single-Point Analysis Method for Quantitating Local Cerebral Blood Flow in Mice.- Effects of Temperature on Oxygen Transport in Sheets and Spheres of Respiring Tissues.- Modeling of the Response of ptO2 in Rat Brain to Changes in Physiological Parameters.- Black Magic and EPR Oximetry.- Axial Oxygen Diffusion in the Krogh Model.- Differentiating Hemodynamic Compromise by the OEF Response to Acetazolamide in Occlusive Vascular Disease.- The Anomalous Einstein-Stokes Behaviour of Oxygen and Other Low Molecular Weight Diffusants.- Gut Dysoxia.- Imaging Oxygen Pressure in the Retina of the Mouse Eye.- Fluorescence-Mediated Detection of a Heterogeneity in a Highly Scattering Media.- Developing Strategies for Three-Dimensional Imaging of Oxygen Tension in the Rodent Retina.- Cerebral PtO2, Acute Hypoxia, and Volatile Anesthetics in the Rat Brain.- Rate of Change in Cerebral Oxygenation and Blood Pressure in Response to Passive Changes in Posture.- Validation of the Cas Neonatal NIRS System by Monitoring VV-ECMO Patients.- Interactions between HIF-1 and Jab1: Balancing Apoptosis and Adaptation.- Past, Present, and Future of Oxygen in Cancer Research.- Benzoate Hydroxylation.- Mitochondrial NADH as the Bellwether of Tissue O2 Delivery.- Process Scale-Up Studies for Protein C Separation Using IMAC.- Hypoxia-Induced Alterations in Hyaluronan and Hyaluronidase.- Rate of Decrease of PO2 from an Arteriole with Arrested Flow.- Measurement of CMRO2 in Neonates Undergoing Intensive Care Using Near Infrared Spectroscopy.- The Pathways of Oxygen in Brain I.- The Pathways of Oxygen in Brain II.- Exogenous and Endogenous Markers of Tumour Oxygenation Status.- The Difficulties in Comparing In Vivo Oxygen Measurements.- Preliminary Study of Simultaneous Multi-Anticoagulant Deficiency Diagnosis by Fiber Optic Multi-Analyte Biosensor.- Circulation Time in Man from Lung to Periphery as an Indirect Index of Cardiac Output.- Factors Controlling Oxygen Utilization.- Amputation Level Viability in Critical Limb Ischaemia.- Hypoxia in Breast Cancer.- Monitoring Metabolite Gradients in the Blood, Liver, and Tumor after Induced Hyperglycemia in Rats with R3230 Flank Tumors Using Microdialysis and Bioluminescence Imaging.- Possible Protective Effects of ?-Tocopherol on Enhanced Induction of Reactive Oxygen Species by 2-Methoxyestradiol in Tumors.- Simultaneous NIR-EPR Spectroscopy of Rat Brain Oxygenation.- Microcirculation and Reperfusion Injury in Organ Transplantation.- Focussing on Genomic and Phenomic Correlations in Respiration of Non-Melanotic Skin Cancers.-Protein C Production.- Modeling Behavior of Protein C during and after Subcutaneous Administration.- Echanisms for Vasoconstriction and Decreased Blood Flow Following Intravenous Administration of Cell-Free Native Hemoglobin Solutions.