Thesevisionswillbecomereality.Thecontributionsfromtheworldsofsmall-scalete- nologies are required to realize them. Invaluable progress towards them was recorded by the very scientists that have joined forces to accomplish the effort presented in this 4-volume collection. It has been a great privilege for me to be at their service, and at the service of the readership, in aiding with its assembly. May I take this oppor- nity to express my gratitude to all of the contributing Chapter Authors, for their - spired and thorough work. For many of them, writing about the history of their s- cialty?eldsofBioMEMSandBiomedicalNanotechnologyhasreallybeenreportingabout their personal, individual adventures through scienti?c discovery and innovation¿a sort xxii FOREWORD of family album, with equations, diagrams, bibliographies and charts replacing Holiday pictures....

Title is also available as part of a set: BioMEMS and Biomedical Nanotechnology (978-0-387-25561-3)

Part I. Application of Microarray Technologies: Electronic Microarray Technology and Applications in Genomics and Proteomics.- Gene Expression Profiling Utilizing Microarray Technology and RT-PCR.- Microarray and Fluidic Chip for Extracellular Sensing.- Cell Physiometry Tools Based on Dielectrophoresis.- Hitting the Spot:The Promise of Protein Microarrays.- Use of Electric Field Array Devices for Assisted Assembly of DNA Nanocomponents and Other Nanofabrication Applications.- Peptide Arrays in Proteomics and Drug Discovery.- From One-bead One-compound Combinatorial Libraries to Chemical Microarrays.- Part II. Advanced Microfluidic Devices and Human Genome Project.- Plastic Microfluidic Devices for DNA and Protein Analyses.- Centrifuge Based Fluidic Platforms.- Sequencing the human genome: A historical perspective on challenges for systems integration.- Part III. Nanoprobes for Imaging, Sensing and Therapy.- Hairpin Nanoprobes for Gene Detection.- Fluorescent Lanthanide Labels with Time-resolved Fluorometry in DNA Analysis.- Role of SNPs and Haplotypes in Human Disease and Drug Development.- Control of Biomolecular Activity by Nanoparticle Antennas.- Sequence-dependent Rigidity of DNA: Influence on DNA-protein interactions and DNA in Nanochannels.- Engineered Ribozymes: Efficient Tools for Molecular Gene Therapy and Gene Discovery.