Molecular and Cellular Signaling

Martin Beckerman
980 g
243x158x32 mm
Biological and Medical Physics

Makes connections between diseases, drugs and signaling in those chapters not specifically devoted to pathogens.
Biophysicists and medical doctors have learned that malfunction of the control layer in cells is responsible for a host of human disorders ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Intended for a broad audience of students and others interested in furthering their understanding of how cells regulate and coordinate their core activities, this overview explains how the cellular control level works. The audience includes students in chemistry, physics and computer science who intend to work in biological and medical physics, and bioinformatics and systems biology. The first five chapters of the book are supply the background and review chapters, after which signaling in the immune, endocrine (hormonal) and nervous systems is explained, as well as cancer, apoptosis and gene regulation
1. Introduction 2.The Control Layer 3. Exploring Protein Structure and Function 4. Macromolecular Forces 5. Protein Folding and Binding 6. Stress and Pheromone Responses in Yeast 7.Two-Component Signaling Systems 8. Organization of Signal Complexes by Lipids, Calcium and Cyclic Amp 9. Signaling by Cells of the Immune System 10. Cell Adhesion and Motility 11. Signaling in the Endocrine System 12. Signaling in the Endocrine and Nervous System through GPCRs 13. Cell Fate and Polarity 14.Cancer 15. Adoptosis 16. Gene Regulation in Eukaryotes 17. Cell Regulation in Bacteria 18. Regulation by Viruses 19. Ion Channels 20. Neural Rhythms 21. Learning and Memory

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