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Principles of Diabetes Mellitus

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Leonid Poretsky
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""Principles of Diabetes Mellitus, Second Edition" is an important update to the comprehensive textbook first published in 2002 and reissued in 2004. It is written for physicians of all specialties who, on a daily basis, deal with an illness which has reached epidemic proportions. The book is also intended for medical students and investigators of all aspects of diabetes.

The last five years have witnessed major developments in our understanding of diabetes and in therapeutic approaches to this disease. Thus, in addition to updating all chapters, the authors added eight new chapters to the second edition. "Principles of Diabetes Mellitus, Second Edition" covers diabetes in all of its aspects - genetics, epidemiology, pathophysiology, clinical manifestations, therapy and prevention."

Second Edition, 2009



Leonid Poretsky

Preface to the first edition

Leonid Poretsky


Chapter 1. The main events in the history of diabetes mellitus

Jacek Zajac, Anil Shrestha, Parini Patel and Leonid Poretsky

PART II. Physiology of glucose metabolism

Chapter 2. Normal glucose homeostasis

Muhammad Z. Shrayyef and John E. Gerich

Chapter 3. Endocrine pancreas.

Barry J. Brass, Zinoviy Abelev, Emilia P. Liao, and Leonid Poretsky

Chapter 4. The role of incretins in insulin secretion

Brock E. Schroeder and Orville Kolterman

Chapter 5. Cellular mechanisms of insulin action

Theodore P. Ciaraldi

Chapter 6. The role of brain in glucose metabolism

Silvana Obici and Paulo José Forcina Martins

PART III. Diagnosis and epidemiology of diabetes

Chapter 7. Diagnostic criteria and classification of diabetes

James P. Leu and Joel Zonszein

Chapter 8. Epidemiology

Shadi Chamany and Bahman P. Tabaei

Chapter 9. Diabetes in culturally diverse populations: from biology to culture

A. Enrique Caballero

PART IV. Genes and diabetes

Chapter 10. Genetics of type 2 diabetes: from candidate genes to genome-wide association analysis

Kevin Brown and Alan R. Shuldiner

Chapter 11. Rodent models of diabetes

Ronald J. Christopher, Koji Takeuchi and Bumsup Lee

PART V - Diabetes Syndromes

Chapter 12. Type 1 diabetes mellitus: epidemiology, genetics, pathogenesis and clinical manifestations

Omar Ali

Chapter 13. Type 2 diabetes mellitus: epidemiology, genetics, pathogenesis and clinical manifestations

Vivian Fonseca and Jennifer John-Kalarickal

Chapter 14. Maturity onset diabetes of the young (MODY): genetics, clinical manifestations and therapy

Markus Stoffel

Chapter 15. Diabetes in pregnancy

Adina E. Schneider, Elliot J.Rayfield, Agustin Busta and Yuriy Gurevich

Chapter 16. Secondary causes of diabetes mellitus

Yana B. Garger, Prajesh M. Joshi, Ashutosh Pareek, Carla M. Romero, Amit K. Seth and Adrienne M. Fleckman

Chapter 17. Syndromes of extreme insulin resistance

George Grunberger and Bianca Alfonso

PART VI. Complications of diabetes

Chapter 18. Acute hyperglycemic syndromes: diabetic ketoacidosis and the hyperosmolar state

Yun Feng and Adrienne M. Fleckman

Chapter 19. Hypoglycemia in diabetes mellitus

Mazen Alsahli and John E. Gerich

Chapter 20. Intake of advanced glycation endproducts; role in the development of diabetic complications

Helen Vlassara, and Gary E. Striker

Chapter 21. Diabetic retinopathy

Ketan Laud and Uri Shabto

Chapter 22. Diabetic nephropathy

James F. Winchester, Donald A. Feinfeld, Nikolas B. Harbord and Alan Dubrow

Chapter 23. Diabetic neuropathy

Russell L. Chin and Michael Rubin

Chapter 24. Peripheral vascular disease in diabetes

Jennifer K. Svahn, Jeffrey S. Kirk, Omar H. Llaguna and Nancy Habib

Chapter 25. The diabetic foot

Dennis Shavelson, John S. Steinberg and Bradley W. Bakotic

Chapter 26. Male sexual dysfunction in diabetes

Barry M. Mason, Albert C. Leung, Michael E. DiSanto and Arnold Melman

Chapter 27. Gastrointestinal manifestations of diabetes

Donald P. Kotler and Stanley Hsu

Chapter 28 Dyslipidemia: pathogenesis and management

Om P. Ganda

Chapter 29 Dermatological complications of diabetes mellitus, allergy to insulin and oral agents

George I. Varghese, Ellen S. Marmur and Mathew C. Varghese

PART VII. Related disorders

Chapter 30. Obesity - genetics, pathogenesis, therapy

William C. Hsu, Kalliopi M. Arampatzi and Christos S. Mantzoros

Chapter 31. Hypertension

Samy I. McFarlane, Ho Won Lee, Sara Choundhry and Nathaniel Winer

Chapter 32. Coronary artery disease and cardiomyopathy

Richard B. Devereux

Chapter 33. Polycystic ovary syndrome

Susan B. Zweig, Marsha C. Tolentino, Marina Strizhevsky and Leonid Poretsky

Chapter 34. Insulin resistance and the metabolic syndrome

Mary Ann Banerji and Rochelle L. Chaiken

Chapter 35. Diabetes and liver disease

Douglas Meyer and Henry C. Bodenheimer, Jr.

Chapter 36. The increased risk of cancer in obesity and type 2 diabetes: potential mechanisms

Emily Jane Gallagher, Ruslan Novosyadlyy, Shoshana Yakar and Derek LeRoith

Chapter 37. Diabetes and sleep disorders

Abhijith Hegde and Steve H. Salzman

Chapter 38. HIV infection and diabetes

Madhu N. Rao, Kathleen Mulligan and Morris Schambelan

PART VIII. Therapy of diabetes mellitus-general principles

Chapter 39. Glycemic goals

David J. Brillon

Chapter 40. Behavioral and educational approaches to diabetes self-management

Maria A. Mendoza, Monique Welbeck and Grishma Parikh

Chapter 41. Dietary therapy of diabetes mellitus

Gladys Witt Strain, Rosalia Doyle and Faith Ebel

Chapter 42. Exercise in the therapy of diabetes mellitus

Sefton Vergano, Rajiv Bhambri and Stephen H. Schneider

Chapter 43. Therapy of type 1 diabetes mellitus

Pejman Cohan and Anne L. Peters

Chapter 44. Treating type 2 diabetes mellitus

Susan Herzlinger and Martin J. Abrahamson

Chapter 45. Prevention of microvascular complications of diabetes - general overview

Vincent Yen

Chapter 46. Psychiatric care of the patient with diabetes

Jennifer L. Kraker and Stephen J. Ferrando

Chapter 47. Management of diabetes and hyperglycemia in the hospital setting

Samantha DeMauro-Jablonski and Silvio E. Inzucchi

Chapter 10. Future of diabetes therapy

Graham T. McMahon

PART IX - Diabetes prevention

Chapter 49. Prevention of type 1 diabetes mellitus

Paolo Pozzilli and Chiara Guglielmi

Chapter 50. Prevention of type 2 diabetes mellitus

Edward S. Horton


Chapter 51. Resources for patients with diabetes

Marina Krymskaya


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