Principles of Diabetes Mellitus, Second Edition is an important update to the comprehensive textbook first published in 2002 and reissued in 2004. It is written for physicians of all specialties who, on a daily basis, deal with an illness which has reached epidemic proportions. The book is also intended for medical students and investigators of all aspects of diabetes.

""Principles of Diabetes Mellitus, Second Edition" is an important update to the comprehensive textbook first published in 2002 and reissued in 2004. It is written for physicians of all specialties who, on a daily basis, deal with an illness which has reached epidemic proportions. The book is also intended for medical students and investigators of all aspects of diabetes.The last five years have witnessed major developments in our understanding of diabetes and in therapeutic approaches to this disease. Thus, in addition to updating all chapters, the authors added eight new chapters to the second edition. "Principles of Diabetes Mellitus, Second Edition" covers diabetes in all of its aspects - genetics, epidemiology, pathophysiology, clinical manifestations, therapy and prevention."

PRINCIPLES OF DIABETES MELLITUS BOOKSecond Edition, 2009LIST OF CONTRIBUTORSPrefaceLeonid PoretskyPreface to the first editionLeonid PoretskyPART IChapter 1. The main events in the history of diabetes mellitusJacek Zajac, Anil Shrestha, Parini Patel and Leonid PoretskyPART II. Physiology of glucose metabolismChapter 2. Normal glucose homeostasisMuhammad Z. Shrayyef and John E. GerichChapter 3. Endocrine pancreas.Barry J. Brass, Zinoviy Abelev, Emilia P. Liao, and Leonid PoretskyChapter 4. The role of incretins in insulin secretionBrock E. Schroeder and Orville KoltermanChapter 5. Cellular mechanisms of insulin actionTheodore P. CiaraldiChapter 6. The role of brain in glucose metabolismSilvana Obici and Paulo José Forcina MartinsPART III. Diagnosis and epidemiology of diabetesChapter 7. Diagnostic criteria and classification of diabetesJames P. Leu and Joel ZonszeinChapter 8. EpidemiologyShadi Chamany and Bahman P. TabaeiChapter 9. Diabetes in culturally diverse populations: from biology to cultureA. Enrique CaballeroPART IV. Genes and diabetesChapter 10. Genetics of type 2 diabetes: from candidate genes to genome-wide association analysisKevin Brown and Alan R. ShuldinerChapter 11. Rodent models of diabetesRonald J. Christopher, Koji Takeuchi and Bumsup LeePART V - Diabetes SyndromesChapter 12. Type 1 diabetes mellitus: epidemiology, genetics, pathogenesis and clinical manifestationsOmar AliChapter 13. Type 2 diabetes mellitus: epidemiology, genetics, pathogenesis and clinical manifestationsVivian Fonseca and Jennifer John-KalarickalChapter 14. Maturity onset diabetes of the young (MODY): genetics, clinical manifestations and therapyMarkus StoffelChapter 15. Diabetes in pregnancyAdina E. Schneider, Elliot J.Rayfield, Agustin Busta and Yuriy GurevichChapter 16. Secondary causes of diabetes mellitusYana B. Garger, Prajesh M. Joshi, Ashutosh Pareek, Carla M. Romero, Amit K. Seth and Adrienne M. FleckmanChapter 17. Syndromes of extreme insulin resistanceGeorge Grunberger and Bianca AlfonsoPART VI. Complications of diabetesChapter 18. Acute hyperglycemic syndromes: diabetic ketoacidosis and the hyperosmolar stateYun Feng and Adrienne M. FleckmanChapter 19. Hypoglycemia in diabetes mellitusMazen Alsahli and John E. GerichChapter 20. Intake of advanced glycation endproducts; role in the development of diabetic complicationsHelen Vlassara, and Gary E. StrikerChapter 21. Diabetic retinopathyKetan Laud and Uri ShabtoChapter 22. Diabetic nephropathyJames F. Winchester, Donald A. Feinfeld, Nikolas B. Harbord and Alan DubrowChapter 23. Diabetic neuropathyRussell L. Chin and Michael RubinChapter 24. Peripheral vascular disease in diabetesJennifer K. Svahn, Jeffrey S. Kirk, Omar H. Llaguna and Nancy HabibChapter 25. The diabetic footDennis Shavelson, John S. Steinberg and Bradley W. BakoticChapter 26. Male sexual dysfunction in diabetesBarry M. Mason, Albert C. Leung, Michael E. DiSanto and Arnold MelmanChapter 27. Gastrointestinal manifestations of diabetesDonald P. Kotler and Stanle