Beschreibung:
The chapters in this book provide an introduction to a range of both well known and less familiar cellular oscillations and serve to illustrate the striking richness of cellular dynamics. The contributions focus particularly on elucidating the basic mechanisms that underlie these oscillations. The essentially quantitative nature of oscillations has long made them an attractive area of study for theoretical biologists, and the application of complementary modelling and experimental approaches can yield insights into oscillatory dynamics that go beyond those that can be obtained by either in isolation. The benefits of this synergy are reflected in the contributions appearing in this book.
The current resurgence in interest in interdisciplinary approaches to cell and molecular biology stems in part from the increasing availability of system-wide data on the state of the components of cellular regulatory networks. Alimiting factor in these approaches is often the lack of suitable ways of characterising a network state in terms of summary quantitative features. Without such features, it is typically difficult to gain new qualitative insight into the operating logic of all but the simplest networks. In this regard, oscillatory phenomena provide ideal exemplars for systems approaches, since oscillations have clear summary features that prove invaluable in combining mathematical models with experimental data.
"The chapters in this book provide an introduction to a range of both well known and less familiar cellular oscillations and serve to illustrate the striking richness of cellular dynamics. The contributions focus particularly on elucidating the basic mechanisms that underlie these oscillations. The essentially quantitative nature of oscillations has long made them an attractive area of study for theoretical biologists, and the application of complementary modelling and experimental approaches can yield insights into oscillatory dynamics that go beyond those that can be obtained by either in isolation. The benefits of this synergy are reflected in the contributions appearing in this book.
The current resurgence in interest in interdisciplinary approaches to cell and molecular biology stems in part from the increasing availability of system-wide data on the state of the components of cellular regulatory networks. Alimiting factor in these approaches is often the lack of suitable ways of characterising a network state in terms of summary quantitative features. Without such features, it is typically difficult to gain new qualitative insight into the operating logic of all but the simplest networks. In this regard, oscillatory phenomena provide ideal exemplars for systems approaches, since oscillations have clear summary features that prove invaluable in combining mathematical models with experimental data."
1. CALCIUM OSCILLATIONS; Ruediger Thul, Tomas C. Bellamy, H. Llewelyn Roderick, Martin D. Bootman, and Stephen Coombes
Abstract
Introduction
Modelling Ca2+ Dynamics
Mechanistic Models
Homogenous Cell Models
Threshold Models
Stochastic Modelling
Concluding Remarks
2. OSCILLATIONS BY THE p53-Mdm2 FEEDBACK LOOP; Galit Lahav
Abstract
Introduction
The p53-Mdm2 Negative Feedback Loop
Oscillations of p53 and Mdm2
The Mechanism of p53-Mdm2 Oscillations
Variability in the Response of Individual Cells
The Potential Function of p53 Oscillations
Conclusion and Key Questions in the Field
3. CAMP OSCILLATIONS DURING AGGREGATION OF DICTYOSTELIUM; William F. Loomis
Abstract
Introduction
Proposed cAMP Oscillatory Circuit
Periodic Motility
Discussion
4. MIN OSCILLATION IN BACTERIA; Joe Lutkenhaus
Abstract
Introduction
Z Ring
The Min System
The Oscillation
Biochemistry of Min Proteins
Models
Conclusions
5. DEVELOPMENT ON TIME; Isabel Palmeirim, Sofia Rodrigues, J. Kim Dale and Miguel Maroto
Abstract
Somitogenesis Is a Strict Time-Controlled Embryonic Process
Time Control during Somite Formation: The Segmentation Clock
The Genetic Complexity Underlying the Segmentation Clock
The Clock and Wavefront Model
Temporal vs Positional Information
Conclusions
6. OSCILLATORY EXPRESSION OF HES FAMILY TRANSCRIPTION FACTORS: INSIGHTS FROM MATHEMATICAL MODELLING; Hiroshi Momiji and Nicholas A.M. Monk
Abstract
Delay-Driven Oscillations in Cellular Signaling Systems
Hes1 as a Cellular Oscillator
Mathematical Modelling of the Hes1 Oscillator
Properties of Delay-Driven Oscillations
Extended Models of Hes1 Regulation
Spatio-Temporal Coordination of Oscillatory Dynamics
Discussion
7. REVERSE ENGINEERING MODELS OF CELL CYCLE REGULATION; Attila Csiksz-Nagy, Bla Novk and John JTyson
Abstract
Bottom-Up Modeling and Reverse Engineering
Physiology of the Cell Cycle
Three Cell Cycle States and Three Cell Cycle Transitions
Cell Cycle Transitions and Bifurcation Points
Reverse Engineering the Molecular Regulatory Network
The Complete Bifurcation Diagram
Cell Cycles and Limit Cycles
Conclusion
8. MITOCHONDRIAL OSCILLATIONS IN PHYSIOLOGY AND PATHOPHYSIOLOGY; Miguel A. Aon, Sonia Cortassa and Brian ORourke
Abstract
Introduction
The Mitochondrial Oscillator of Heart Cells: The Pathophysiological Domain
The Theoretical Approach
The Mitochondrial Oscillator in the Physiological Domain
Spatial Aspects: ROS and Mitochondrial Criticality
From Mitochondrial Dynamics to Whole Heart Arrhythmias
Conclusions
9. RESPIRATORY OSCILLATIONS IN YEASTS; David Lloyd
Abstract
Introduction
Minute-Long Oscillations in S. cerevisiae
Ultradian (t 30-50min) Oscillations in Synchronous Cultures of Yeasts
Schizosaccharomyces pombe
Candida utilis
Saccharomyces cerevisiae: Self Synchronized Continuous Culture
Mitochondrial Respiratory Dynamics in Vivo During Growth
Oxidative Stress and Signalling by ROS
Circadian Oscillations in Yeasts
Other Oscillations
Functions of Oscillations
10. STOCHASTIC PHASE OSCILLATOR MODELS FOR CIRCADIAN CLOCKS; Jacques Rougemont and Felix Naef
Background
Mathematics of Phase Models
Theory vs. Data
Conclusion