Multiple Analyses in Clinical Trials
Fundamentals for Investigators
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ISBN-13:
9780387007274
Veröffentl:
2003
Erscheinungsdatum:
30.07.2003
Seiten:
436
Autor:
Lemuel A Moyé
Gewicht:
775 g
Format:
242x162x27 mm
Sprache:
Englisch
Beschreibung:
Concentrating on the rationale for the analyses, the difficulties posed by their interpretation, easily understood solutions, and useful problem sets, this book will help clinical investigators understand multiple analysis procedures and key issues. It is written for advanced medical students, clinical investigators at all levels, research groups within the pharmaceutical industry, regulators at the local, state, and federal level, and biostatisticians.
Multiple analyses in clinical trials involves numerous statisticalhypotheses within a single experiment. This book provides anonmathematical introduction to the commmon issues in these types oftrials. The audience is medical students, clinical investigatorspharmaceutical researchers, biostatisticians, and epidemiologists.
Prologue.- Fundamentals of Clinical Trial Design.- Multiple Analyses and the Random Experiment.- The Lure and Complexity of Multiple Analyses.- Multiple Analyses and Multiple Endpoints.- to Multiple Dependent Analyses I.- Multiple Dependent Analyses II.- to Composite Endpoints.- Multiple Analyses and Composite Endpoints.- to Subgroup Analyses.- Subgroups II: Effect Domination and Controversy.- Subgroups III: Confirmatory Analyses.- Multiple Analyses and Multiple Treatment Arms.- Combining Multiple Analyses.- Conclusions: The Two-Front War.
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