Multiple Analyses in Clinical Trials

Fundamentals for Investigators
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ISBN-13:
9780387007274
Erscheinungsdatum:
01.08.2003
Seiten:
436
Autor:
Lemuel A. Moyé
Gewicht:
775 g
Format:
242x162x27 mm
Serie:
Statistics for Biology and Health
Sprache:
Englisch
Beschreibung:

Concentrating on the rationale for the analyses, the difficulties posed by their interpretation, easily understood solutions, and useful problem sets, this book will help clinical investigators understand multiple analysis procedures and key issues. It is written for advanced medical students, clinical investigators at all levels, research groups within the pharmaceutical industry, regulators at the local, state, and federal level, and biostatisticians.
Multiple analyses in clinical trials involves numerous statistical hypotheses within a single experiment. This book provides a
nonmathematical introduction to the commmon issues in these types of
trials. The audience is medical students, clinical investigators,
pharmaceutical researchers, biostatisticians, and epidemiologists.
Introduction * The Rudiments: Methodologic Roots of Clinical Trial Design * Multiple Analyses and the Random Experiment * The Lure and Complexity of Multiple Analyses *
Multiple Analyses and Multiple Endpoints * Introduction to Multiple Dependent Analyses * Multiple Dependent Analyses 2 * Introduction to Composite Endpoints * Multiple Analyses and Composite Endpoints * Introduction to Subgroup Analyses * Subgroups II: Effect Domination and Controversy * Subgroups III: Confirmatory Analyses * Multiple Analyses and Multiple Treatment Arms * Combining Multiple Analyses * Conclusions

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