This edition of Flavonoids in Health and Disease reflects the major advances made in this area of research over the last five years and the involvement of flavonoids and phenolic compounds in biochemical, physiological, and pharmacological processes implicated in disease prevention.

Part I: Occurrence and Analysis 1. Phenolic Acids in Fruits and Vegetables 2. Flavonoids in Herbs 3. The Relationship between the Phenolic Composition and the Antioxidant Activity of Fruits and Vegetables Part II: Characterization, Chemical, and Biological Properties 4. Applications of Flavonoid Analysis and Identification Tech-niques: Isoflavones (Phytoestrogens) and 3-Deoxyanthocyanins 5. Synthesis, Identification, Quantification and Chemical Reactivity of Methylated Flavan-3-ols 6. Investigation of Flavonoids and Their in Vivo Metabolite Forms Using Tandem Mass Spectrometry 7. Effects of Flavonoids on the Oxidation of Low-Density Lipoprotein and Atherosclerosis Part III: Cell Interactions in Vivo and in Vitro 8. Phytochemicals and Brain Aging: A Multiplicity of Effects 9. Flavonoids: Neuroprotective Agents? Modulation of Oxi-dative Stress-Induced MAP Kinase Signal Transduction 10. Mitochondrial Actions of Flavonoids and Isoflavonoids 11. Gene Modulation of HaCaT Cells Induced by Pine Bark Extract 12. Cytoprotective and Cytotoxic Effects of Flavonoids Part IV: Absorption, Metabolism, and Bioavailability 13. Understanding the Bioavailability of Flavonoids through Studies in Caco-2 Cells 14. Metabolism in the Small Intestine and Gastrointestinal Tract 15. Absorption of Quercetin Glycosides 16. Bioavailability of Flavanol Monomers 17. Absorption and Metabolism of Hydroxycinnamates