Featuring contributions from leading experts, Protein Discovery Technologies provides comprehensive coverage of the principles, techniques, strategies, and broad range of applications of protein discovery. This volume presents in-depth discussions of various methods for protein discovery, including bioinformatics, interaction cloning, protein purification, phage display, non-primate models, and chemical targeting. It also explores biological themes through the examination of cell death, angiogenesis, hemostasis, development, signal transduction, transcriptional control, cell cycle control, neurobiology, and quality control.

Discovery of Vascular Permeability Factor (VPF, VEGF, VPF/VEGF, VEGF-A165). Tumor Necrosis Factor and Its Family Members. Blood-Brain Barrier Models for Investigating CNS Pathologies. Identification of Activation of Latent TGFß as Principal In Vivo Function of Integrin avß6. Purification of Basic Fibroblast Growth Factor by Heparin Affinity. How It Came to Pass that Interferon Was Used as an Angiogenesis Inhibitor. Use of Phage Display to Discover Inhibitors of Cell Migration. Combinatorial Mapping of Vascular Zip Codes by In Vivo Phage Display. Chasing Elusive Cellular Prion Protein Receptor. Discovery of Molecular Chaperone GRP78 and GRP94 Inducible by Endoplasmic Reticulum Stress. Origin of Sphingomyelin Pathway. Endotoxin-Induced Myocarditis: A New Pathophysiological Entity in Systemic Inflammatory Response Syndrome. Discovery of DOCK180 Superfamily of Exchange Factors. Discovery of Extracellular Matrix Degradome as Novel Endogenous Regulators of Angiogenesis and Tumor Growth. RING Finger Proteins as E3 Ubiquitin Ligases. Discovery of Chemical Nature of Cross-Links in Collagen: A Personal Retrospective. Discovery of SPARC as Prototype for Matricellular Proteins.