Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume One: Biology and Pathophysiology provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This volume discusses topics such as tumor microenvironment in hepatocellular carcinoma, endoplasmic reticulum stress and unfolded protein response, effects of cirrhosis and hepatitis on the prognosis of HCC, mitochondrial metabolism, next generation sequencing, and telomerase. In addition, it discusses exosomes role in HCC progression, metastasis and chemokines.

1. Cell origin, biology and pathophysiology hepatocellular carcinoma2. Tumor microenvironment in HCC3. Role of endoplasmic reticulum stress and unfolded protein response (UPR) in the onset and progression of hepatocellular carcinoma4. Effect of cirrhosis and hepatitis on the prognosis of hepatocellular carcinoma5. The role of cellular necrosis in hepatocellular carcinoma6. Tyrosine kinases: their role in hepatocellular carcinoma7. Mitochondrial metabolism in the progression of hepatocellular carcinoma8. Role of transcription factors in growth and metastasis in hepatocellular carcinoma9. The role of next generation sequencing in HCC progression10. Functional mechanisms of microRNAs and Long non-coding RNAs in hepatocellular carcinoma11. ROS mediated pathways: Potential role in liver cancer biology and therapy12. Telomerase in hepatocellular carcinoma13. Exosomes role in hepatocellular carcinoma progression and metastasis. An update on the diagnosis of liver cancer14. A review of chemokines in HCC