Insulin: Deficiency, Excess and Resistance in Human Disease provides an overview of the role of insulin in the pathogenesis of prevalent non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, and cancer, along with a comprehensive review of insulin replacement therapies and novel cardioprotective and insulin-sensitizing drugs. Notable advances in precision diagnosis and therapy for single gene subtypes of diabetes in recent years are also discussed.The discovery of insulin and its lifesaving introduction into clinical practice is one of the most celebrated accomplishments of medical science. However, despite decades of progress and major technical advances, the goal of providing insulin replacement therapy that truly mimics normal physiology remains elusive.

Forewordby Steve EdelmanIntroduction and Prefaceby Andre J KrentzSection 1: Normal Physiology: Insulin Secretion and Insulin Action1. Insulin Biosynthesis and Releaseby Gabriela da Silva Xavier 2. Classic Metabolic Actions of Insulin in Humansby Andrew J Krentz 3. Non-classic Effects of Insulinby George KingSection 2a: Role of Insulin in Human Disease4. Type 1 Diabetes Pathogenesis: Lessons Learned and Questions that Remainby Adebola Matthew Giwa, Abdel Hamad, Zahra Omidian, Angela Yang, Neha Majety, Tiffany Jackson, Kusuma Ananth, Mohanraj Sadasivam, Marjan Behzadirad, Thomas Donner and Rizwan Ahmed 5. Insulin Therapy - A Century of Progressby Geremia Bolli 6. Treatment and Prevention of Type 1 Diabetes in the 21st Centuryby Jay S Skylar, David Baidal, and J Sosenko 7. Differentiation of Diabetes by Pathophysiology: A Focus on Insulin Deficiency vs Insulin Resistanceby Adrian Heald Section 2b: Syndromes of Insulin Excess8. Congenital Hyperinsulinismby Katherine Lord and Diva D De Leon 9. Hypoglycemic Disorders in Adultsby Adrian Vella and Maheswaran Dhanasekaran Section 2c: Insulin Resistance in Human Disease10. Obesity and Insulin Resistance: Pathophysiology and Principles of Therapyby Rita Basu 11. The Cardiometabolic Syndrome and Vascular Disease: Pivotal Role of Insulinby Michael D Shapiro, Trevor Caldarera, and Jordan Tannenbaum 12. Insulin, IGF-1, and Cancer: Pathogenic Considerations and Therapeutic Opportunitiesby John Vincent Reynolds and Jessie Andrea Elliott 13. Insulin and Neurodegenerative Diseasesby Heather A Ferris 14. Non-pharmacological, Pharmacological, and Surgical Options for Obesity-related Cardiometabolic Disorders: Metabolic and Clinical Impactby Alexander Dimitri Miras, Mariana Abdel-Malek, and Darmiga Thayabaran 15. Syndromes of Severe Insulin Resistance: Lessons from Natureby Andrew J Krentz