Cell and Gene Therapies for Neurologic Diseases, Volume 205 comprehensively covers the scientific background, translational efforts, clinical developments and registered biologics that have entered into clinical practice. Coverage includes types of therapies available and in development, and best practice uses for a variety of neurological disorders including Parkinson’s, Huntington’s, ALS, stroke, spinal cord RP, demyelination, and epilepsy. As the emergence of gene and cellular therapeutics has changed the clinical landscape for a variety of disorders, and is now ready to do so for neurological diseases, these therapeutic modalities currently complement, and may in time, supplant small molecule drugs.

Section 1. Cellular Therapies1. Introduction to stem cell biology and its role in treating neurologic disorders2. History of cellular grafting for CNS repair - A clinical perspective3. Autologous vs. heterologous cell replacement strategies for Parkinson disease and other neurologic diseasesSection 2. Gene therapies4. Viral vectors and gene delivery to the central nervous system5. Viral versus Non-viral approachesSection 3. General Considerations (for cell and gene therapies)6. Clinical/surgical considerations7. Ethics of gene and cell therapy development for neurological disorders8. Clinical trial designs and endpoints9. Immunology of such therapies10. Scaling of cell and gene therapies to population11. The Health economics of cell and gene therapiesSection 4. Disease specific interventions using cells and genes12. Disease specific interventions: The use of cell and gene therapies for Parkinson disease13. Using gene or cell therapies to treat Huntington’s disease14. Disorders of the motorneuron including ALS and SMA15. Gene and cell-based therapies for retinal and optic nerve disease16. Disease specific interventions using cell therapies for spinal cord disease/injury17. Stem and progenitor cell-based therapy of myelin disorders18. Cell and gene therapy in neuro-oncology