The Cell in Mitosis is a collection of papers presented at the First Annual Symposium held on November 6-8, 1961 under the provisions of The Wayne State Fund Research Recognition Award. Contributors focus on the complexities posed by the cell in division and consider topics such as the chemical prerequisites for cell division, the role of the centriole in division cycles, development of the cleavage furrow, chemical aspects of the isolated mitotic apparatus, histone variability, and actin polymerization. This volume is organized into 11 chapters and begins with an overview of cell division, with reference to the basic essential mechanisms of mitogeneses underlying the emergence of the elegant geometries of mitosis. An account of the congression of chromosomes onto metaphase configuration and progression through telophase is also given. The next chapters explore the identity and role of the centriole in the whole life cycle of cell behavior; the fine structure of animal cells during cytokinesis; the mechanism of saltatory particle movements during mitosis; and how chemical and physical agents disrupt the mitotic cycle. A chapter is devoted to the holotrichous ciliate, Tetrahymena pyriformis, paying attention to its fine structure during mitosis. This book will be of interest to physiologists, electron microscopists, light microscopists, biochemists, and others who want to know more about the various aspects of cell division.

Contributors To The SymposiumPrefaceIntroduction Function of Flagellate and Other Centrioles in Cell Reproduction I. Introduction and General Considerations II. Functions, Types, and Life Cycles of Flagellate Centrioles III. Participation of Centrioles in Formation of Achromatic Figure IV. Function of Achromatic Figure in Chromosomal Movement V. Birefringence of the Central Spindle References Discussion I. Introduction II. The Centriole in Division Cycles III. The Centriole in Reproduction of Extranuclear Apparatus IV. The Role of the Centriole in Cytokinesis V. The Behavior of the Centriole in Regulation of Cell Activity VI. Summary Hypothesis References The Central Spindle and the Cleavage Furrow I. Introduction II. Development of the Midbody III. Development of the Cleavage Furrow References General Discussion Saltatory Particle Movements and Their Relation to the Mitotic Apparatus I. Introduction II. Particle Movements III. Electron Microscope Studies of Dividing Eggs IV. General Discussion References Discussion General Discussion The Fine Structure of Tetrahymena pyriformis during Mitosis I. Introduction II. General Morphology III. Vegetative Division References Discussion Chemical Prerequisites for Cell Division I. Introduction II. Approach to the Problem III. Experimental Separation of Cell Growth and Cell Division IV. What Is the Chemical Nature of the Last Prerequisite for Cell Division? References Discussion General Discussion Chemical Aspects of the Isolated Mitotic Apparatus I. Introduction II. Biochemical Composition III. Physicochemical Characteristics IV. Conclusion References Discussion General Discussion Studies on the Disruption of the Mitotic Cycle I. Introduction II. Concluding Remarks References Discussion References General Discussion The Histones: Syntheses, Transitions, and Functions I. Introduction II. Histone Variability III. Conclusion References Discussion General Discussion Contractility I. Contraction of Long Chain Polymers II. Actin Polymerization III. Contraction in Muscle in General IV. Structure and Contraction of Striated Muscle References Discussion References Author Index Subject Index