Features new to the second edition of this handbook include measurement scales used in research, breakthroughs in pharmacogenomics, epidemiology, genetics, psychophysiology and pharmacology, and enhanced therapeutic strategies and outcome measures for patient care and management.

Preface, Contributors, 1. A Conceptual History of Anxiety and Depression, 2. Epidemiology of Depression and Anxiety, 3. Comorbidity of Depression and Anxiety, 4. Anxiety, Depression, and Personality, 5. Is There a Common Etiology for Depression and Anxiety?, 6. Measurements of Depression and Anxiety Disorders, 7. Combining Psychotherapy and Pharmacotherapy for Depression and Anxiety, 8. Genetics of Depression, 9. Genetics of Anxiety, 10. Stress-Responsive Neurohormones in Depression and Anxiety, 11. Neuropeptide Alterations in Depression and Anxiety Disorders, 12. Immunology in Anxiety and Depression, 13. Brain Imaging in Depression and Anxiety, 14. Neurobiology of Anxiety and Depression, 15. Intracellular Signaling Transduction Dysregulation in Depression and Possible Future Targets for Antidepressant Therapy: Beyond the Serotonin Hypothesis, 16. Norepinephrine in Depression and Anxiety, 17. Benzodiazepines, Benzodiazepine Receptors, and Endogenous Ligands, 18. Antidepressants for the Treatment of Depression and Anxiety Disorders: Same Mechanism of Action?, 19. Studies on the Neurobiology of Depression, 20. Animal Models of Subtypes of Depression, 21. Pathogenesis of Depression: Reconsideration of Neurotransmitter Data by Depletion Paradigms, 22. Effects of Antidepressants on Specific Neurotransmitters: Are Such Effects Relevant to Therapeutic Actions?, 23. Pharmacotherapy of Depression: The Acute and Long-Term Perspective, 24. Pharmacotherapy of Bipolar Disorder, 25. Development of New Treatment Options for Depression, 26. The Depressed Patient: From Nonresponse to Complete Remission, 27. Pharmacogenetics of Mood Disorders: Is There a Future?, 28. Theories of the Etiology of Anxiety, 29. Animal Models of Anxiety and Anxiolytic Drug Action, 30. Provocation of Anxiety States in Humans and Its Possible Significance for the Pathogenesis of These Disorders, 31. Pharmacotherapy of Anxiety Disorders, 32. Pharmacotherapy of Mixed Anxiety/Depression Disorders, 33. New and Emerging Therapies for Anxiety, 34. Scales Used in Depression and Anxiety Research, Index