New discoveries in genetics, molecular, and cell biology are not only enhancing our understanding of the etiology and progression of disease, but are finding applications in the development of new drugs or the implementation of new kinds of therapy. This book provides an in-depth review of emerging areas in biomedical research at the interface of science and clinical medicine. Written by a team of well-known experts, Lipidology: Translational Medical Science presents an authoritative overview of key advances in biomedical research and reviews the most important recent advances in lipidology, highlighting their relationship to cardiovascular disease.

List of contributors viiForeword xiPreface xiiiAcknowledgements xiv1. The assembly of very low density lipoproteins in the liver 1S-O. Olofsson and L. Asp2. Cardiovascular implications of partial, tissue-specific silencing of MTP 15C.C. Shoulders3. Acyl CoA: Diacylglycerol acyltransferases (DGATs) as therapeutic targetsfor cardiovascular disease 31J.S. Millar and J.T. Billheimer4. The biochemical and physiological roles of ACAT1 and ACAT2 incholesterol homeostasis and atherosclerosis 41R.G. Lee and L.L. Rudel5. Overview of intestinal lipid metabolism 55T.A. Miettinen and H. Gylling6. The role of non-cholesterol sterols in the pathogenesis of atherosclerosisand their modulation by the sitosterolaemia locus 63E.L. Klett and S.B. Patel7. FXR: the molecular link between bile acid and lipid metabolism 69T. Claudel, E. Sturm, B. Staels and F. Kuipers8. Overview of HDL and reverse cholesterol transport 81P. Barter9. LXR as a therapeutic target for atherosclerosis 93I.G. Schulman and R.A. Heyman10. Endothelial lipase and the regulation of HDL metabolism 101K.O. Badellino and W. Jin11. Cholesteryl ester transfer protein (CETP) inhibition as a therapeuticstrategy for raising HDL-cholesterol levels and reducing atherosclerosis 111D.J. RaderContentsPrelims 14/7/05 4:44 pm Page v12. Overview of insulin resistance and the metabolic syndrome 119N. Sattar and B. Mukhopadhyay13. Peroxisome proliferator activated receptors and energy metabolism 137P. Gervois, J-C. Fruchart and B. Staels14. Adipocytes and their secretory products 153J.B. Prins15. Regulation of adipocyte triglyceride storage 165F. Karpe and G.D. Tan16. Role of innate immunity in atherosclerosis: immune recognition,immune activation and the atherosclerotic process 175J-M. Fernández-Real17. Role of CD44 in atherogenesis and its potential role as a therapeutic target 191E. Puré18. Lipoxygenases: potential therapeutic target in atherosclerosis 207L. Zhao and C.D. Funk19. Role of secretory phospholipase A2 isozymes (Lp-PLA2) 219C.H. MacpheeIndex