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Supercritical Fluid Technology for Drug Product Development
ISBN-13:
9780203021378
Veröffentl:
2004
Seiten:
632
Autor:
Peter York
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
2 - DRM Adobe
Sprache:
Englisch
Beschreibung:
Interconnecting the fundamentals of supercritical fluid (SCF) technologies, their current and anticipated utility in drug delivery, and process engineering advances from related methodological domains and pharmaceutical applications, this volume unlocks the potential of supercritical fluids to further the development of improved pharmaceutical products. Outlining means of establishing scalable SCF processes in compliance with good manufacturing practices, the book presents new data on particle formation mechanisms and engineering methods, confirming the versatility and flexibility of SCF-based particle production for drug delivery.
Chemistry and Materials Design for Pharmaceutical Applications. Phase Equilibrium in Solid-Liquid-Supercritical Fluid Systems. Mechanisms of Particle Formation Using Supercritical Fluids. Methods of Particle Production. Colloid and Interface Science for CO2-based Pharmaceutical Processes. Production of Powders for Respiratory Drug Delivery. Control of Physical Form of Drug Substances. Supercritical Fluid Impregnation of Polymers for Drug Delivery. Formulation of Controlled Drug Release Systems. Processing of Biological Materials. Asymmetric Catalysis in Supercritical Fluids. Analytical and Semi-Preparative Supercritical Fluid Chromatography in Drug Discovery. Drug Extraction Development and Potential of Critical Fluid Technology in the Neutraceutical Industry. Scale-Up Issues for Supercritical Fluid Processing in Compliance with GMP
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