As a major mainstay of clinical focus and research today, bipolar disorder affects millions of individuals across the globe with its extreme and erratic shifts of mood, thinking and behavior. Edited by a team of experts in the field, The Bipolar Book: History, Neurobiology, and Treatment is a testament and guide to diagnosing and treating this exceedingly complex, highly prevalent disease.Featuring 45 chapters from an expert team of contributors from around the world, The Bipolar Book delves deep into the origins of the disorder and how it informs clinical practice today by focusing on such topics as bipolar disorder occurring in special populations, stigmatization of the disease, the role genetics play, postmortem studies, psychotherapy, treatments and more.Designed to be the definitive reference volume for clinicians, students and researchers, Ayseg?l Yildiz, Pedro Ruiz and Charles Nemeroff present The Bipolar Book as a "must have" for those caregivers who routinely deal with this devastating disease.

Section I: Clinical PresentationChapter 1. History of Bipolar Manic-Depressive DisorderRoss J. Baldessarini, Jes?s P?rez, Paola Salvatore, Katharina Trede, and Carlo MagginiChapter 2. Update on Epidemiology, Risk Factors, and Correlates of Bipolar Spectrum DisorderKathleen R. Merikangas and Diana PaksarianChapter 3. Presentation, Clinical Course, and Diagnostic Assessment of Bipolar DisorderErica Snook, Keitha Moseley-Dendy, and Robert M. A. HirschfeldChapter 4. Differential Diagnosis and Bipolar Spectrum DisordersJean-Michel Azorin and Raoul BelzeauxChapter 5. Diagnosing Bipolar Disorder in Children and AdolescentsAndrew J. Freeman, Kiki Chang, and Eric A. YoungstromChapter 6. Effects of Public Awareness and Stigmatization on Accurate and Timely Diagnosis of Bipolar DisorderGiampaolo Perna, Tatiana Torti, and Alessandra AlciatiSection II: Insights on Pathophysiology & Future TreatmentsPart I: Molecular BiologyChapter 7. Oxidative Damage and Its Treatment ImpactGislaine Tezza Rezin and Ana Cristina AndreazzaChapter 8. The Role of Signal Transduction Systems in the Pathophysiology and Treatment of Bipolar DisorderRichard S. Jope, Eleonore Beurel, Marta Pardo, Erika Abrial, and Charles B. NemeroffChapter 9. Cellular Resilience and Neurodegeneration and Their Impact on the Treatment of Bipolar DisorderGabriel Rodrigo Fries and Fl?vio KapczinskiChapter 10. Immune Mechanisms and Inflammation and Their Treatment ImpactAlice Russell, Carmine M. Pariante, and Valeria MondelliChapter 11. Circadian Rhythms, Sleep, and Their Treatment ImpactJoshua Z. Tal and Michelle PrimeauChapter 12. Hypothalamic-Pituitary-Adrenal Axis and Hypothalamic-Pituitary-Thyroid Axis and Their Treatment ImpactMichael Bauer and Timothy DinanChapter 13. Translating Biomarkers and Biomolecular Treatments to Clinical Practice: Assessment of Hypothesis-Driven Clinical Trial DataMarcus V. Zanetti, Alexandre Loch, and Rodrigo Machado-VieiraPart II: GeneticChapter 14. The Apple and the Tree: What Family and Offspring Studies of Bipolar Disorder Show About Mechanisms of Risk and PreventionGuillermo Perez Algorta, Anna Van Meter, and Eric A. YoungstromChapter 15. The Emerging Genetics of Bipolar DisorderRoy H. PerlisPart III: CognitionChapter 16. Cognitive Impairments and Everyday Disability in Bipolar IllnessColin A. Depp, Alexandrea L. Harmell, and Philip D. HarveyPart IV: NeuroimagingChapter 17. Structural and Functional Magnetic Resonance Imaging Findings and Their Treatment ImpactMarguerite Reid Schneider, David E. Fleck, James C. Eliassen, and Stephen M. StrakowskiChapter 18. Magnetic Resonance Spectroscopy Findings and Their Treatment ImpactMarsal Sanches, Frank K. Hu, and Jair C. SoaresChapter 19. The Use of Molecular Imaging to Investigate Bipolar Disorder: Findings and Treatment ImplicationsAllison Greene, Christopher Bailey, and Alexander NeumeisterPart V: Postmortem studiesChapter 20. Postmortem Findings in Bipolar Disorder and Their Treatment ImpactDost ?ng?rSection III: Current TreatmentsPart I: Pharmacological TreatmentsChapter 21. Treatment of ManiaPaul E. Keck, Susan L. McElroy, and Ayseg?l YildizChapter 22. Pharmacological Treatment Bipolar DepressionKeming Gao, Renrong Wu, Heinz Grunze, and Joseph R. CalabreseChapter 23. Maintenance Treatments in Bipolar DisorderPaul A. Kudlow, Danielle S. Cha, Roger S. McIntyre, and Trisha SuppesChapter 24. Improving Early Diagnosis: An Unmet Need for Early Intervention in Bipolar DisordersGabriele Sani and Giacomo SalvadoreChapter 25. Alternative and Complementary Treatments for Bipolar DisorderJanet WozniakPart II: Somatic Non-Pharmacological TreatmentsChapter 26. Electroconvulsive Therapy and Bipolar DisorderLauren S. Liebman, Gabriella M. Ahle, Mimi C. Briggs, and Charles H. KellnerChapter 27. Neuromodulative Treatments for Bipolar Disorder: Repetitive Transcranial Magnetic Stimulation, Vagus Nerve Stimulation, and Deep Brain StimulationChristina Switala, Sabrina Maria Gippert, Sarah Kayser, Bettina Heike Bewernick, and Thomas Eduard SchlaepferPart III: Adverse treatment effectsChapter 28. Management of Metabolic and Endocrine Effects of Medications Used to Treat Bipolar DisordersRichard BalonChapter 29. Neurological, Cognitive, and Neuroprotective Effects of Treatments Used in Bipolar DisorderJanusz K. RybakowskiChapter 30. Treatment-Induced Mood Instability: Treatment-Emergent Affective Switches and Cycle AccelerationRenrong Wu, Keming Gao, Joseph R. Calabrese, and Heinz GrunzePart IV: PsychotherapyChapter 31. Cognitive Behavioral Therapy and PsychoeducationDina Popovic, Jan Scott, and Francesc ColomChapter 32. Family-Focused Therapy, Interpersonal and Social Rhythm Therapy, and Dialectical Behavioral TherapyNoreen A. Reilly-Harrington, Stephanie Roberts, and Louisa G. SylviaPart V: ComorbidityChapter 33. Nature and Management of Co-occurring Psychiatric Illnesses in Bipolar Disorder Patients: Focus on Anxiety SyndromesGustavo H. V?zquez, Leonardo Tondo, and Ross J. BaldessariniChapter 34. Management of Cyclothymia and Comorbid Personality DisordersGiulio Perugi and Giulia VannucchiChapter 35. Management of Comorbid Substance or Alcohol AbuseIhsan Salloum and Pedro RuizChapter 36. Medical Comorbidity in Bipolar DisorderJelena Vrublevska and Konstantinos N. FountoulakisPart VI: SuicidalityChapter 37. Clinical Management of Suicidal RiskLeonardo Tondo and Ross J. BaldessariniPart VII: Pregnancy & LactationChapter 38. Management of Bipolar Disorder During Pregnancy and LactationJulie Hyman and D. Jeffrey NewportPart VIII: Children & AdolescentsChapter 39. Management of Bipolar Disorder in Children and AdolescentsLuis R. Patino, Nina R. McCune, and Melissa P. DelBelloPart IX: ElderlyChapter 40. Bipolar Disorder in the ElderlyElizabeth A. Crocco, Samir Sabbag, and Rosie E. CurielSection IV: Future ResearchChapter 41. Placebo Response in Clinical Trials of Bipolar Disorder: Potential Causes, Potential SolutionsBret R. Rutherford, Steven P. Roose, and Jane M. TandlerChapter 42. Strategies for Improving Randomized Trial Evidence for Treatment of Bipolar DisorderAyseg?l Yildiz, Juan Undurraga, Eduard Vieta, Dina Popovic, Sarah Wooderson, and Allan H. YoungChapter 43. Challenges in Designing Reliable and Feasible Trials for Treatment of Bipolar DisorderRobert M. Post and Ayseg?l YildizChapter 44. Sequential Multiple Assignment Randomized TrialsFan Wu, Eric B. Laber, and Emanuel SeverusChapter 45. Traditional and Novel Research Synthesis Approaches to Support Evidence-Based Treatment DecisionsLevente Kriston and Ayseg?l Yildiz