Fifty Years of Magnetoencephalography celebrates the first half century of research in and clinical applications of magnetoencephalography (MEG). It catalogs and documents its evolution as a means of imaging the ongoing activity of the brain and the activation of particular neuronal networks within it that mediate sensory motor and higher functions like language. The volume's first section looks at the discovery of MEG and its first tentative applications by three of its founders. The following sections detail the rapid progress in the development of the instrumentation necessary for recording noninvasively the magnetic signals on the head that are associated with the brain activity; improvements in the techniques for analyzing the magnetic signals and reconstructing, on their basis, the functional images of brain activity; and improvements in our understanding of the nature and significance of those signals. Subsequent sections of the book detail the main clinical applications of MEG in localizing brain areas that contain sources of epileptiform activity and areas encompassing parts of functional networks essential for motor and sensory function as well as for language that have become an essential part of planning for brain surgery in many epilepsy and tumor surgery centers around the world. In addition, several chapters describe the most current efforts aiming at expanding the utility of MEG in clinical diagnosis and theoretical research.

PREFACESection One: The Beginnings1. THE FIRST MEG REPORT: 1968David CohenMassachusetts Institute of Technology2. THE BEGINNING OF BIOMAGNETISM AND MEG RESEARCH IN FINLAND IN THE 1970sToivo KatilaHelsinki University of Technology3. A VIEW FROM NEAR THE BEGINNING OF MEG: AFTER HALF A CENTURYLloyd KaufmanNew York UniversitySection Two: Technical Advances4. PHYSIOLOGICAL BASES OF MEG AND EEGYoshio OkadaBoston Children's Hospital and Harvard Medical School5. WHICH PART OF THE NEURONAL CURRENT CAN BE DETERMINED BY EEG?A.S. Fokas, P Hashemzadeh and R. LeahyUniversity of Cambridge and University of Southern California6. MEG SOURCE ESTIMATION: TRANSFORMING THE SENSOR-LEVEL SIGNALS TO ESTIMATES OF BRAIN ACTIVITYMatti S. H?m?l?inenMassachusetts General Hospital and Harvard Medical School7. The Need for and the Road to Hybrid MEG-MRIRisto J. IlmoniemiAalto University School of Science8. MAGNETOENCEPHALOGRAPHY USING OPTICALLY PUMPED MAGNETOMETERSElena Boto, Niall Holmes, Tim Tierney, James Leggett, Ryan Hill, Stephanie Mellor, Gillian Roberts, Gareth Barnes, Richard Bowtell and Matt BrookesUniversity of Nottingham and the Wellcome Trust Centre for Neuroimaging, University College LondonSection Three: Applications to Epilepsy9. GUIDELINES AND PRACTICAL CONSIDERATIONS FOR MAPPING EPILEPTIFORM ACTIVITY WITH MAGNETOENCEPHALOGRAPHYRoozbeh Rezaie, James W. Wheless, and Abbas Babajani-Feremi.The University of Tennessee Health Science Center10. BEYOND THE IRRITATIVE ZONE: USE OF MEG TO CHARACTERIZE ASPECTS OF THE EPILEPTOGENIC ZONEEduardo M. Castillo, Tara Kleineschay, Milena Korostenskaja , James Baumgartner and Ki Hyeong LeeFlorida Hospital for Children11. USE OF MULTIPLE FREQUENCY BANDS IN MEG FOR CHARACTERIZATION OF EPILEPSYWoorim Jeong and Chun Kee ChungSeoul National University12. CAN MAGNETOENCEPHALOGRAPHY IDENTIFY THE EPILEPTOGENIC PATHOLOGY IN CHILDREN?Won Seok Chang and Hiroshi OtsuboThe Hospital for Sick Children, University of Toronto13. REVISIONAL ANALYSIS OF EEG AND MEG BASED ON COMPREHENSIVE EPILEPSY CONFERENCENobukazu Nakasato, Akitake Kanno, Makoto Ishida, Shin-ichiro OsawaMasaki Iwasaki, Yosuke Kakisaka and Kazutaka JinTohoku University Graduate School of Medicine14. EPILEPTIC SLOW WAVE ACTIVITYStefan Rampp and Martin Kaltenh?userUniversity Hospital, Erlangen UniversitySection Four: Somatosensory, Motor and Language Mapping15. CLINICAL MOTOR MAPPING WITH MEG: HISTORICAL APPROACHES, CHALLENGES AND RECOMMENDATIONS FOR BEST PRACTICEWilliam Gaetz, PhD.The Children's Hospital of Philadelphia, University of PennsylvaniaChristos Papadelis, Boston Children's Hospital, Harvard Medical School andTony Wilson, University of Nebraska Medical Center16. INVESTIGATIONS OF THE SOMATOSENSORY SYSTEM WITH MEG: FROM RESEARCH TO CLINICAL APPLICATIONSXavier De Ti?geandH?pital Erasme, Universit? libre de Bruxelles andVeikko Jousm?ki, Aalto University School of Science and Nanyang Technological University17. LANGUAGE MAPPING WITH MEG: CLINICAL AND RESEARCH APPLICATIONSPanagiotis G. SimosUniversity of Crete, School of MedicineSusan M. BowyerHenry Ford Hospital and Wayne State UniversityKyousuke KamadaAsahikawa Medical UniversitySection Five: Exploring the Brain Mechanisms of Cognition18. READING, READING ACQUISITION AND READING DISABILITY (DYSLEXIA) Panagiotis G. SimosUniversity of Crete School of Medicine19. MEG DECODING COGNITIVE FUNCTION WITH MEGDimitrios PantazisMassachusetts Institute of Technology20. HOW BRAIN RHYTHMS REFLECT COGNITIVE PROCESSESJoachim GrossWestphalian-Wilhelms-University of MuensterSection Six: Neuronal Correlates of Cognitive and Affective Disorders21. APPLICATIONS OF MEG TO AUTISM SPECTRUM DISORDERKristina Safar, Margot J. TaylorHospital for Sick Children, TorontoJunko Matsuzaki and Timothy P.L. RobertsChildren's Hospital of Philadelphia22. FUNCTIONAL WOUNDS OF AN INVISIBLE INJURY: VISUALIZING COGNITION IN PTSDBenjamin T. Dunkley and Margot J. TaylorHospital for Sick Children, University of Toronto23. IDENTIFYING NEURAL ABNORMALITIES IN SCHIZOPHRENIAJ. Christopher EdgarChildren's Hospital of Philadelphia andGregory A. MillerUniversity of California, Los Angeles24. BIOMARKERS IN PEDIATRIC MEGJulia M. Stephen, Isabel Solis, John F.L. Pinner, Felicha T. Candelaria-CookThe Mind Research Network, Lovelace Biomedical and Environmental Research Instituteand The University of New Mexico25. MAGNETOENCEPHALOGRAPHY IN Alzheimer's disease: CORRELATION WITH CURRENT BIOMARKERSDavid L?pez-Sanz; Jaisalmer de Frutos-Lucas; Gianluca Susi, and Fernando Maest?Complutense University of MadridPOSTSCRIPT