Neuroprotection is becoming an increasingly recognized and important part of critical care and perioperative medicine. As human beings survive increasingly severe life-threatening injuries and complex surgical interventions, it has become clear that neurologic injury and dysfunction is a primary driver of long-term outcome and disability. Neuroprotection is currently under-recognized as the primary objective in promoting recovery from life-threatening injuries, illnesses, and procedures.To address this knowledge gap, Neuroprotection in Critical Care and Perioperative Medicine provides a concise review of the current state of the art of clinical care and research. Within the context of critical care, the specific topics covered will include the primary forms of brain injury on which neuroprotection research and intervention has traditionally focused, such as traumatic brain injury, cardiac arrest, acute ischemic stroke, and intracranial hemorrhage, as well as CNS injuries related to sepsis and acute respiratory distress syndrome, mechanical circulatory support, and premature birth. Within the context of perioperative care, the specific topics covered will include anesthetic and perioperative strategies to reduce brain injury from cardiac surgery, aortic surgery and endovascular repair, carotid endarterectomy, vascular and endovascular neurosurgery, and other major surgical procedures.

PROTECTION STRATEGIES1. Physiologic Modulators of Neural Injury After Brain and Spinal Cord InjuryW. Dalton Dietrich2. Pharmacologic NeuroprotectionNino Stocchetti and Marco CarbonaraCLINIMETRICS OF NEUROPROTECTION3. Imaging Assessment of Brain InjuryMatthew A. Warner, Carlos Marquez de la Plata, David S. Liebeskind, and Ramon Diaz-Arrastia4. Tissue Biomarkers and NeuroprotectionAxel Petzold5. Neurophysiological Monitoring and NeuroprotectionAws Alawi, Michael Reznik, Jan Claassen6. Neurological and Functional Outcomes AssessmentSuzan Uysal and Stephan A. Mayer7. Assessment of Postoperative Cognitive DeclineSuzan Uysal and David L. ReichNEUROPROTECTION IN CRITICAL CARE8. Neuroprotection for Traumatic Brain InjuryJonathan J. Ratcliff and David W. Wright9. Neuroprotection for Cardiac ArrestJoseph Pitcher and David B. Seder10. Neuroprotection for Acute Ischemic StrokeDiana Mayor and Michael Tymianski11. Neuroprotection for Intracranial HemorrhageJulius Griauzde, Neeraj Chaudhary, Joseph J Gemmete, Aditya S Pandey, Guohua Xi12. Neuroprotection for Mechanical Circulatory SupportLauren E Dunn, Joshua Z Willey, Ronald M Lazar13. Neuroprotection in Sepsis and Acute Respiratory Distress SyndromeNeha S. Dangayach, Charles L Francoeur, Stephan A. Mayer, Tarek Sharshar14. Neuroprotection for Premature Birth and Neonatal Brain InjuryEugene Chang15. Neuroprotection for Spinal Cord InjuryChristopher S. Ahuja and Michael FehlingsPERI-OPERATIVE NEUROPROTECTION16. Neuroprotection for Valvular and Coronary Bypass SurgeryKarsten Bartels G. Burkhard Mackensen17. Neuroprotection for Aortic Surgery and StentingJared W. Feinman and John G. Augoustides18. Neuroprotection for Carotid Endarterectomy and StentingZirka H. Anastasian and Eric J. Heyer19. Neuroprotection for Vascular and Endovascular NeurosurgeryTravis R Ladner, Nishant G Kumar, Lucy He, J Mocco20. Neuroprotection for Spine SurgeryJess W. Brallier and Jonathan S. Gal21. Neuroprotection for General, Orthopedic, Peripheral Vascular and ENT SurgeryMagdy Selim