Nearly 44 million people have Alzheimer's or related dementia worldwide, according to the Alzheimer's Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer's and other forms of dementia.First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer's disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer's disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer's diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer's disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer's disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients.

Part I: Mental Health in Dementia 1. Measures of depression in Alzheimer's disease Ahmed A. Moustafa, Wafa Jaroudi, Lily Bilson and Mohamad El Haj 2. The nature of depression in dementia: A narrative review Ahmed A. Moustafa, Phoebe Bailey, Wafa Jaroudi, Lily Bilson and Mohamad El Haj 3. Stress and anxiety in dementia Ahmed A. Moustafa, Shimaa Adel Heikal and Wafa JaroudiPart II: Advanced Topics in Dementia Research 4. Alzheimer's disease in the pupil: Pupillometry as a biomarker of cognitive processing in Alzheimer's Disease Ahmed A. Moustafa and Mohamad El Haj 5. Cognitive and neural correlates of vitamin D deficiency: Focus on healthy aging and Alzheimer's Disease Ahmed A. Moustafa, Wafa Jaroudi and Abdrabo Soliman 6. The effect of Alzheimer's Disease on the thalamus Ahmed A. Moustafa and Rasu Karki 7. Using big data methods to understand Alzheimer's Disease Ahmed A. Moustafa, Samuel L. Warren and Hany Alashwal 8. Operational aspects of deep learning solutions for Alzheimer's Disease Ahmed A. Moustafa, Dustin van der Haar and Samuel L. WarrenPart III: Treatment of Dementia 9. Treatment of depression in Alzheimer's Disease Ahmed A. Moustafa, Lily Bilson and Wafa Jaroudi 10. Developing a vulnerability to negative affect scale for music interventions for people with dementia Ahmed A. Moustafa, Sandra Garrido and Wafa Jaroudi 11. Using music to improve mental health in people with dementia Ahmed A. Moustafa, Wafa Jaroudi and Sandra Garrido 12. The efficacy of Donepezil for the treatment of Alzheimer's Disease Ahmed A. Moustafa and Samuel L. Warren